VEGF Receptor 1 (FLT1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF
Recommend Dilution	IF: 100-500 Positive control: HepG2 cell Predicted cell location: Cytoplasm, Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1303-1316 amino acids of human fms-related tyrosine kinase 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	fms related tyrosine kinase 1
Database Link	NP_002010 Entrez Gene 2321 Human UniProt ID P17948
Background	This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains; a transmembrane segment; and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A; VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells; placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened; soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Synonyms	FLT; FLT-1; VEGFR-1; VEGFR1
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion

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