AMACR Mouse Monoclonal Antibody [Clone ID: 2F3-C11-B12]

Specifications

Product Data
Clone Name	2F3-C11-B12
Applications	IF, WB
Recommend Dilution	WB: 1:1000, IF: 1:100
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for AMACR antibody: purified recombinant human AMACR(C-terminus) protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	42 kDa
Gene Name	alpha-methylacyl-CoA racemase
Database Link	NP_055139 Entrez Gene 25284 Rat UniProt ID Q9UHK6
Background	This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)-and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described.
Synonyms	AMACRD; CBAS4; RACE; RM
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Primary bile acid biosynthesis

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