NUMB Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: K562, hela, skov3, NIH/3T3 and Raji cells, human testis tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human NUMB
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	71 kDa
Gene Name	NUMB, endocytic adaptor protein
Database Link	NP_003735 Entrez Gene 18222 MouseEntrez Gene 29419 RatEntrez Gene 8650 Human UniProt ID P49757
Background	The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.
Synonyms	C14orf41; c14_5527; S171
Reference Data
Protein Pathways	Notch signaling pathway

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