Interferon gamma (IFNG) Mouse Monoclonal Antibody [Clone ID: MD-1]

Specifications

Product Data
Clone Name	MD-1
Recommend Dilution	ELISA, ELISPOT, Immunohistochemistry
Reactivity	Human, Rhesus Macaque
Host	Mouse
Clonality	Monoclonal
Immunogen	IFN-gamma
Formulation	Prior to lyophilization: 0.5 ml PBS + 125 mM trehalose.
Concentration	lot specific
Purification	Ion exchange chromatography.
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	16.7 kDa
Gene Name	interferon, gamma
Database Link	NP_000610 Entrez Gene 3458 Human UniProt ID P01579
Background	The monoclonal antibody to human IFN-? (clone MD-1) was first described in 1985. It has shown to neutralize the antiviral activity of both natural and recombinant human IFN-? and in a Western Blot the antibody reacts with the 20 kDa and 25 kDa polypeptides present in natural human IFN-? (van der Meide P.H. et al. 1985). The MD-1 antibody has been descriped as useful in a sandwich ELISA (Wassenaar A. et al. 1995, Wierenga E.A. et al. 1990 and Yazdanbakhsh M et al. 1993). Further, the antibody has proven to cross react with rhesus macaque IFN-? and can be used for immunohistochemical staining of frozen tissues (Wassenaar A. et al. 1995 and Kap Y. et al. 2009). The MD-1 antibody has been reported for use in intracellular flow cytometric analysis (Hamann D. et al. 1996). Other available formats: unconjugated and FITC labeled.
Synonyms	IFG; IFI
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Allograft rejection, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Proteasome, Regulation of autophagy, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Type I diabetes mellitus

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