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Hgs (NM_008244) Mouse Untagged Clone
CAT＃: MC221480
Hgs (untagged) - Mouse HGF-regulated tyrosine kinase substrate (Hgs), transcript variant 2, (10ug)
CNY 9,980.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | Hgr; Hrs; tn; ZFYVE8 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC221480 representing NM_008244
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGGCGAGGCAGCGGCACCTTCGAGCGTCTCCTAGACAAAGCCACCAGCCAGCTTCTGTTGGAGACAG ACTGGGAGTCCATTCTACAGATCTGCGACCTGATCCGTCAGGGGGACACACAAGCAAAATATGCTGTAAA CTCCATCAAGAAGAAGGTTAATGATAAGAACCCACACGTGGCTTTGTATGCTCTGGAGGTGATGGAGTCT GTGGTAAAGAACTGTGGCCAGACAGTCCATGATGAAGTGGCCAACAAACAGACCATGGAAGAACTGAAGG AGCTGCTGAAGAGGCAAGTGGAAGTTAATGTTCGGAACAAGATCTTGTACCTGATCCAGGCCTGGGCACA TGCCTTCCGGAACGAACCCAAGTACAAGGTGGTCCAGGACACATACCAGATCATGAAGGTAGAAGGACAT GTCTTCCCTGAATTTAAGGAAAGTGATGCCATGTTCGCTGCTGAAAGAGCCCCTGACTGGGTGGATGCTG AGGAATGCCATCGGTGCAGAGTACAGTTTGGGGTGGTGACCCGCAAGCATCACTGCCGAGCATGTGGGCA GATCTTCTGTGGCAAGTGCTCCTCCAAGTACTCCACCATCCCCAAGTTCGGCATTGAGAAGGAGGTGCGC GTGTGTGAGCCCTGCTATGAGCAGCTGAACAAGAAGGCAGAAGGGAAGGCTTCCTCTACCACTGAGCTGC CCCCAGAGTACCTGACCAGCCCCCTGTCACAGCAGTCTCAGCTGCCCCCAAAGCGGGATGAGACAGCCCT GCAGGAAGAGGAGGAGCTACAGCTGGCTCTGGCCCTATCACAGTCAGAGGCTGAGGAGAAAGAGAGGATG AGACAGAAAACAACATATACAGCACATCCAAAGGCAGAGCCCACGCCCTTGGCTTCCTCTGCGCCCCCAG CTGGCAGCCTGTATTCCTCGCCTGTGAACTCATCAGCACCTCTGGCTGAGGACATCGACCCTGAGCTTGC AAGATACCTCAACCGGAACTACTGGGAGAAGAAACAGGAGGAAGCACGGAAGAGCCCCACACCATCTGCA CCTGTGCCCCTGACAGAGCCTGCTGCCCAGCCTGGAGAAGGACATACAGCCCCCAACAGCATGGCAGAGG CTCCTCTTCCAGAGACAGACTCTCAGCCCATAACTCCCTGCAGCGGCCCCTTTAGTGAGTACCAGAATGG GGAGTCGGAGGAGAGCCATGAGCAGTTCCTCAAGGCCCTGCAGAATGCCGTGAGCACTTTTGTCAACCGC ATGAAGAGCAACCACATGCGGGGACGCAGCATCACCAACGACTCGGCTGTGCTGTCACTCTTCCAGTCCA TCAACACCATGCACCCGCAGCTGCTCGAGCTGCTCAACCAGCTGGATGAGCGCAGGCTGTACTACGAGGG CCTTCAGGACAAGCTGGCACAGATACGTGACGCCCGAGGGGCTCTGAGCGCCCTGCGTGAAGAACACAGG GAGAAGCTGCGCCGGGCAGCTGAGGAGGCTGAGCGTCAACGCCAGATCCAGCTGGCACAGAAACTGGAGA TCATGAGACAGAAGAAGCAGGAGTACCTGGAGGTGCAGAGACAGCTAGCTATCCAGCGCCTGCAGGAACA GGAGAAGGAACGGCAGATGCGTCTGGAGCAACAGAAGCAGACTGTCCAGATGCGCGCCCAGATGCCTGCC TTTCCCTTGCCTTATGCCCAGCTCCAGGCTATGCCCACGGCTGGGGGTGTACTCTACCAGCCCTCAGGCC CAACCAGCTTCCCTGCCACCTTCAGCCCAGCAGGCTCAGTAGAGGGCTCTCCGATGCATGGTGTGTATAT GAGCCAGCCAGCCCCAGCCACTGGCCCCTACCCCAGCATGCCTGGCACAACAGCAGATCCCAGCATGGTC AGCGCCTACATGTACCCAACAGGTGCCCCTGGGGCACAGGCAGCCCCTCAGGCCCAGGCCGGGCCCACCA CCAGTCCTGCCTACTCCTCCTACCAGCCCACACCAACCCCAGGCTACCAGAGCGTGGCTTCTCAGGCCCC ACAGAGCCTCCCAGCCATCTCACAGCCTCCACAGACCAGCAACATAGGCTACATGGGGAGCCAGCCAATG TCCATGGGCTACCAGCCGTACAATATGCAGAATCTCATGACCGCCCTTCCCGGGCAGGATGCGTCTCTGC CAGCCCAGCAGCCCTACATCCCAGGGCAGCAGCCCCTGTACCAGCAGATGGCCCCCAGCACCGGCCCTCC CCAGCAGCAACCCCCTGTGGCCCAGCCAGCGCCTACACAGGGACCGCCAGCACAGGGCAGTGAGGCCCAG CTCATCTCCTTTGACTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_008244 |
| Insert Size | 2328 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_008244.3, NP_032270.3 |
| RefSeq Size | 2905 bp |
| RefSeq ORF | 2328 bp |
| Locus ID | 15239 |
| UniProt ID | Q99LI8 |
| Gene Summary | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. This difference results in a protein (isoform 2) that is one amino acid shorter than isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG210580 | Hgs (tGFP-tagged) - Mouse HGF-regulated tyrosine kinase substrate (Hgs) |
CNY 6,370.00 |
|
| MG227581 | Hgs (tGFP-tagged) - Mouse HGF-regulated tyrosine kinase substrate (Hgs) transcript variant 2, (10ug) |
CNY 8,460.00 |
|
| MR227581 | Hgs (Myc-DDK-tagged) - Mouse HGF-regulated tyrosine kinase substrate (Hgs), transcript variant 2 |
CNY 7,700.00 |
|
| MR227581L3 | Lenti ORF clone of Hgs (Myc-DDK-tagged) - Mouse HGF-regulated tyrosine kinase substrate (Hgs), transcript variant 2 |
CNY 9,600.00 |
|
| MR227581L4 | Lenti ORF clone of Hgs (mGFP-tagged) - Mouse HGF-regulated tyrosine kinase substrate (Hgs), transcript variant 2 |
CNY 9,600.00 |
