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XRN2 (NM_012255) Human Tagged ORF Clone
CAT＃: RC223980
XRN2 (Myc-DDK-tagged)-Human 5'-3' exoribonuclease 2 (XRN2)
ORF Plasmid: tGFP
"NM_012255" in other vectors (4)
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CNY 10,432.00
| Cited in 1 publication. |
Product images
CNY 300.00
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC223980 representing NM_012255
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGAGTCCCGGCGTTCTTCCGCTGGCTCAGCCGCAAGTACCCGTCCATCATAGTCAACTGCGTGGAAG AGAAGCCAAAAGAATGCAATGGTGTAAAGATTCCAGTTGATGCCAGTAAACCTAATCCAAATGATGTGGA GTTTGATAATCTGTATTTGGATATGAATGGAATCATCCATCCCTGTACTCATCCTGAAGACAAACCAGCA CCAAAAAATGAAGATGAAATGATGGTTGCAATTTTTGAGTACATTGACAGACTTTTCAGTATTGTAAGAC CAAGAAGACTTCTCTACATGGCAATAGATGGAGTGGCACCACGTGCTAAAATGAACCAGCAGCGTTCAAG GAGGTTCAGGGCATCAAAAGAAGGAATGGAAGCAGCAGTCGAGAAGCAGCGAGTCAGGGAAGAAATATTG GCAAAAGGTGGCTTTCTTCCTCCAGAAGAAATAAAAGAAAGATTTGACAGCAACTGTATTACACCAGGAA CTGAATTCATGGACAATCTTGCTAAATGCCTTCGCTATTACATAGCTGATCGTTTAAATAATGACCCTGG GTGGAAAAATTTGACAGTTATTTTATCTGATGCTAGTGCTCCTGGTGAAGGAGAACATAAAATCATGGAT TACATTAGAAGGCAAAGAGCCCAGCCTAACCATGACCCAAATACTCATCATTGTTTATGTGGAGCAGATG CTGATCTCATTATGCTTGGCCTTGCCACACATGAACCGAACTTTACCATTATTAGAGAAGAATTCAAACC AAACAAGCCCAAACCATGTGGTCTTTGTAATCAGTTTGGACATGAGGTCAAAGATTGTGAAGGTTTGCCA AGAGAAAAGAAGGGAAAGCATGATGAACTTGCCGATAGTCTTCCTTGTGCAGAAGGAGAGTTTATCTTCC TTCGGCTTAATGTTCTTCGTGAGTATTTGGAAAGAGAACTCACAATGGCCAGCCTACCATTCACATTTGA TGTTGAGAGGAGCATTGATGACTGGGTTTTCATGTGCTTCTTTGTGGGAAATGACTTCCTCCCTCATTTG CCATCGTTAGAGATTAGGGAAAATGCAATTGACCGTTTGGTTAACATATACAAAAATGTGGTACACAAAA CTGGGGGTTACCTTACAGAAAGTGGTTATGTCAATCTGCAAAGAGTACAGATGATCATGTTAGCAGTTGG TGAAGTTGAGGATAGCATTTTTAAAAAGAGAAAGGATGATGAGGACAGTTTTAGAAGACGACAGAAAGAA AAAAGAAAGAGAATGAAGAGAGATCAACCAGCTTTCACTCCTAGTGGAATATTAACTCCTCATGCCTTGG GTTCAAGAAATTCACCAGGTTCTCAAGTAGCCAGTAATCCGAGACAAGCAGCCTATGAAATGAGGATGCA GAATAACTCTAGTCCTTCGATATCTCCTAATACGAGTTTCACATCTGATGGCTCCCCGTCTCCATTAGGA GGAATTAAGCGAAAAGCAGAAGACAGTGACAGTGAACCTGAGCCAGAGGATAATGTCAGGTTATGGGAAG CTGGCTGGAAGCAGCGGTACTACAAGAACAAATTTGATGTGGATGCAGCTGATGAGAAATTCCGTCGGAA AGTTGTGCAGTCGTACGTTGAAGGACTTTGCTGGGTTCTTAGATATTATTACCAGGGCTGTGCTTCCTGG AAGTGGTATTATCCATTTCATTATGCACCATTTGCTTCAGACTTTGAAGGCATTGCAGACATGCCATCTG ATTTTGAGAAGGGTACGAAACCGTTTAAACCACTAGAACAACTTATGGGGGTATTTCCAGCTGCAAGTGG TAATTTTCTACCTCCATCATGGCGGAAGCTCATGAGTGATCCTGATTCTAGTATAATTGACTTCTATCCT GAAGATTTTGCTATTGATTTGAATGGGAAGAAATATGCATGGCAAGGTGTTGCTCTCTTGCCATTCGTGG ATGAGCGAAGGCTACGAGCTGCCCTAGAAGAGGTATACCCAGACCTCACTCCAGAAGAGACCAGAAGAAA CAGCCTTGGAGGTGATGTCTTATTTGTGGGGAAACATCACCCACTCCATGACTTCATTTTAGAGCTGTAC CAGACAGGTTCCACAGAGCCAGTGGAGGTACCCCCTGAACTATGTCATGGGATTCAAGGAAAGTTTTCTT TGGATGAAGAAGCCATTCTTCCAGATCAAATAGTATGTTCTCCTGTTCCTATGTTAAGGGATCTGACACA GAACACTGTAGTCAGTATTAATTTTAAAGACCCACAGTTTGCTGAAGATTACATTTTTAAAGCTGTAATG CTTCCAGGAGCAAGAAAGCCAGCAGCAGTACTGAAACCTAGTGACTGGGAAAAATCCAGCAATGGACGGC AGTGGAAGCCTCAGCTTGGCTTTAACCGTGACCGGAGGCCTGTGCACCTGGATCAGGCAGCCTTCAGGAC TTTGGGCCATGTGATGCCAAGAGGCTCAGGAACTGGCATTTACAGCAATGCTGCACCACCACCTGTGACT TACCAGGGAAACTTATACAGGCCGCTTTTGAGAGGACAAGCCCAGATTCCAAAACTTATGTCAAATATGA GGCCCCAGGATTCCTGGCGAGGTCCTCCTCCCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGC TGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCTTCCAGCCAAACCAGTACCAG ATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAG AAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAAT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC223980 representing NM_012255
Red=Cloning site Green=Tags(s) MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPA PKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEIL AKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMD YIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLP REKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHL PSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKE KRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLG GIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASW KWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYP EDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELY QTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVM LPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVT YQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQ MLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_012255 |
| ORF Size | 2850 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_012255.5 |
| RefSeq Size | 3449 bp |
| RefSeq ORF | 2853 bp |
| Locus ID | 22803 |
| UniProt ID | Q9H0D6 |
| Domains | DUF251 |
| Protein Pathways | RNA degradation |
| MW | 108.4 kDa |
| Gene Summary | This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition
,Patidar, PL;Viera, T;Morales, JC;Singh, N;Motea, EA;Khandelwal, M;Fattah, FJ;,
Sci Rep
,PubMed ID 32859985
[XRN2]
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Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC223980L3 | Lenti ORF clone of Human 5'-3' exoribonuclease 2 (XRN2), Myc-DDK-tagged |
CNY 9,030.00 |
|
| RC223980L4 | Lenti ORF clone of Human 5'-3' exoribonuclease 2 (XRN2), mGFP tagged |
CNY 12,832.00 |
|
| RG223980 | XRN2 (tGFP-tagged) - Human 5'-3' exoribonuclease 2 (XRN2) |
CNY 7,890.00 |
|
| SC115463 | XRN2 (untagged)-Human 5'-3' exoribonuclease 2 (XRN2) |
CNY 10,448.00 |
