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p107 (RBL1) (NM_183404) Human Untagged Clone
CAT＃: SC109715
RBL1 (untagged)-Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 2
CNY 7,072.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CP107; p107; PRB1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_183404, the custom clone sequence may differ by one or more nucleotides
ATGTTCGAGGACAAGCCCCACGCTGAGGGGGCGGCGGTGGTCGCCGCAGCCGGGGAGGCGCTACAGGCCC TGTGCCAGGAGCTGAACCTGGACGAGGGGAGCGCGGCCGAAGCCCTGGACGACTTTACTGCCATCCGAGG CAACTACAGCCTAGAGGGAGAAGTTACACACTGGTTGGCATGTTCATTATATGTTGCATGCCGCAAAAGC ATTATTCCCACGGTTGGAAAGGGTATCATGGAAGGCAACTGTGTTTCACTTACCAGAATACTACGTTCAG CTAAATTAAGTTTAATACAATTTTTTAGTAAAATGAAGAAATGGATGGACATGTCAAATCTACCACAAGA ATTTCGTGAACGTATAGAAAGGCTAGAGAGAAATTTTGAGGTGTCTACTGTAATATTCAAAAAATATGAG CCAATTTTTTTAGATATATTTCAAAATCCATATGAAGAACCACCAAAGTTACCACGAAGCCGGAAGCAGA GGAGGATTCCTTGCAGTGTTAAGGATCTGTTTAATTTCTGTTGGACACTTTTTGTTTATACTAAGGGTAA TTTTCGGATGATTGGGGATGACTTAGTAAACTCTTATCATTTACTTCTATGCTGCTTGGATCTGATTTTT GCCAATGCGATTATGTGCCCAAATAGACAAGACTTGCTAAATCCATCATTTAAAGGTTTACCATCTGATT TTCATACTGCTGACTTTACGGCTTCTGAAGAGCCACCCTGCATCATTGCTGTACTGTGTGAACTGCATGA TGGACTTCTCGTAGAAGCAAAAGGAATAAAGGAGCACTACTTTAAGCCATATATTTCAAAACTCTTTGAC AGGAAGATATTAAAAGGAGAATGCCTCCTGGACCTTTCAAGTTTTACTGATAATAGCAAAGCAGTGAATA AGGAGTATGAAGAGTATGTTCTAACTGTTGGTGATTTTGATGAGAGGATCTTTTTGGGAGCAGACGCAGA AGAGGAAATTGGAACACCTCGAAAGTTCACTCGTGACACCCCATTAGGGAAACTGACAGCACAGGCTAAT GTGGAGTATAACCTTCAACAGCACTTTGAAAAAAAAAGGTCATTTGCACCTTCTACCCCACTGACCGGAC GGAGATATTTACGAGAAAAAGAAGCAGTCATTACTCCTGTTGCATCAGCCACCCAAAGTGTGAGCCGGTT ACAGAGTATTGTGGCTGGTCTGAAAAATGCACCAAGTGACCAACTTATAAATATTTTTGAATCTTGTGTG CGTAATCCTGTGGAAAACATTATGAAAATACTAAAAGGAATAGGAGAGACTTTCTGTCAACACTATACTC AATCAACAGATGAACAGCCAGGATCTCACATAGACTTTGCTGTAAACAGACTAAAGCTGGCAGAAATTTT GTATTATAAAATACTAGAGACTGTAATGGTTCAGGAAACACGAAGACTTCATGGAATGGACATGTCAGTT CTTTTAGAGCAAGATATATTTCATCGTTCCTTGATGGCTTGTTGTTTGGAAATTGTGCTCTTTGCCTATA GCTCACCTCGTACTTTTCCTTGGATTATTGAAGTTCTCAACTTGCAACCATTTTACTTTTATAAGGTTAT TGAGGTGGTGATCCGCTCAGAAGAGGGGCTCTCAAGGGACATGGTGAAACACCTAAACAGCATTGAAGAA CAGATTTTGGAGAGTTTAGCATGGAGTCACGATTCTGCACTGTGGGAGGCTCTCCAGGTTTCTGCAAACA AAGTTCCTACCTGTGAAGAAGTTATATTCCCAAATAACTTTGAAACAGGAAATGGAGGAAATGTGCAGGG ACATCTTCCCCTGATGCCAATGTCTCCTCTAATGCACCCAAGAGTCAAGGAAGTTCGAACTGACAGTGGG AGTCTTCGAAGAGATATGCAACCATTGTCTCCAATTTCTGTCCATGAACGCTACAGTTCTCCTACCGCAG GGAGTGCTAAGAGAAGACTCTTTGGAGAGGACCCCCCAAAGGAAATGCTTATGGACAAGATCATAACAGA AGGAACAAAATTGAAAATCGCTCCTTCTTCAAGCATTACTGCTGAAAATGTATCAATTTTACCTGGTCAA ACTCTTCTAACAATGGCCACAGCCCCAGTAACAGGAACAACAGGACATAAAGTTACAATTCCATTACATG GTGTCGCAAATGATGCTGGAGAGATCACACTGATACCTCTTTCCATGAATACAAATCAGGAGTCCAAAGT CAAGAGTCCTGTATCACTTACTGCTCATTCATTAATTGGTGCTTCTCCAAAACAGACCAATCTGACTAAA GCACAAGAGGTACATTCAACTGGAATAAACAGGCCAAAGAGAACTGGGTCCTTAGCACTATTTTACAGAA AGGTCTATCATTTGGCAAGTGTACGCTTACGTGATCTATGTCTAAAACTGGATGTTTCAAATGAGTTACG AAGGAAGATATGGACGTGTTTTGAATTCACTTTAGTTCACTGTCCTGATCTAATGAAAGACAGGCATTTG GATCAGCTCCTCCTTTGTGCCTTTTATATCATGGCAAAGGTAACAAAAGAAGAAAGAACTTTTCAAGAAA TTATGAAAAGTTATAGGAATCAGCCCCAAGCTAATAGTCACGTATATAGAAGTGTTCTGCTGAAAAGTAT TCCAAGAGAAGTTGTGGCATATAATAAAAATATAAATGATGACTTTGAAATGATAGATTGTGACTTAGAA GATGCTACAAAAACACCTGACTGTTCCAGTGGACCAGTGAAAGAGGAAAGAGGTGATCTTATAAAATTTT ACAATACAATATATGTAGGAAGAGTGAAGTCATTTGCACTGAAATACGACTTGGCGAATCAGGACCATAT GATGGATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCC CAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGT ACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGA >OriGene 5' read for NM_183404 unedited
TAATACCGACTTCACCTATNAGTGGANCGGCACCGCGNAATTNCGGCCACGAAGGGCGCC CTGGGNAGAGGAGAAAGAAGTCGGGGGCCGTGGCGCGCAGCCCGCGGGGCCTGAAGGGAT GTTCGAGGACAAGCCCCACGCTGAGGGGGCGGCGGTGGTCGCCGCAGCCGGGGAGGCGCT ACAGGCCCTGTGCCAGGAGCTGAACCTGGACGAGGGGAGCGCGGCCGAAGCCCTGGACGA CTTTACTGCCATCCGAGGCAACTACAGCCTAGAGGGAGAAGTTACACACTGGTTGGCATG TTCATTATATGTTGCATGCCGCAAAAGCATTATTCCCACGGTTGGAAAGGGTATCATGGA AGGCAACTGTGTTTCACTTACCAGAATACTACGTTCAGCTAAATTAAGTTTAATACAATT TTTTAGTAAAATGAAGAAATGGATGGACATGTCAAATCTACCACAAGAATTTCGTGAACG TATAGAAAGGCTAGAGAGAAATTTTGAGGTGTCTACTGTAATATTCAAAAAATATGAGCC AATTTTTTTAGATATATTTCAAAATCCATATGAAGAACCACCAAAGTTACCACGAAGCCG GAAGCAGAGGAGGATTCCTTGCAGTGTTAAGGATCTGTTTAATTTCTGTTGGACACTNTN TGTTTATACTAAGGGTAATTNTCGGATGATTGGGGATGACTTANTAAACTCTTATCATTT ACTTCTATGCTGCTAGGATCTGATNTTTGCCAATGCGATTATGTGCCCAAATANGACAGA CTTTGCTAACCATCATTTAAGGGTTACATCTGATNTTATACTGCTGACTTACGGCTNNCT GAGAGCACCTGCATCATTGCTGTACTGGGNGACTGCATGATGGACTNCTCGTAAAGCAAA GGGATAAGGAGCCCTCTCTAGCCCTTATTCAAACTCTTGCAGGAGATTAAAGGAAATGCC TCTGACCTTNCAGTTACGTATAGCAAC >Forward primer walk for NM_183404 unedited
CTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTT CCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGAA GCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGT TGGATTTCAGATTAACAGTCAGTAACTGTTAATCCTGCCTCTTTTTTTTTTTTTCTTTTT TGGCCAAGTTACTACTATACTAATAAAATATGAAATGTTAAAAAAAAAAAAAAAAAACTC GACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAACAGATCCCGGGTGGCATCCCT GTGACCCCTCCCCAGTGCCTCTCCTGGCCCTGGAAGTTGCCACTCCAGTGCCCACCAGCC TTGTCCTAATAAAATTAAGTTGCATCATTTTGTCTGACTAGGTGTCCTTCTATAATATTA TGGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_183404 |
| Insert Size | 2950 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_183404.1, NP_899662.1 |
| RefSeq Size | 3371 bp |
| RefSeq ORF | 3045 bp |
| Locus ID | 5933 |
| UniProt ID | P28749 |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Cell cycle, TGF-beta signaling pathway |
| Gene Summary | The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Phosphatidylinositol 3-Kinase/Protein Kinase C-Induced Phosphorylation of Sp1 and p107 Repressor Release Have a Critical Role in Histone Deacetylase Inhibitor-Mediated Depression of Transcription of the Luteinizing Hormone Receptor Gene
,Ying Zhang, Mingjuan Liao, and Maria L. Dufau,
Mol. Cell. Biol.,Sep 2006; 26: 6748 - 6761.
[RBL1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207017 | RBL1 (Myc-DDK-tagged)-Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 2 |
CNY 7,064.00 |
|
| RC207017L1 | Lenti ORF clone of Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 2, Myc-DDK-tagged |
CNY 9,464.00 |
|
| RC207017L2 | Lenti ORF clone of Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 2, mGFP tagged |
CNY 11,970.00 |
|
| RC207017L3 | Lenti ORF clone of Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 2, Myc-DDK-tagged |
CNY 11,970.00 |
|
| RC207017L4 | Lenti ORF clone of Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 2, mGFP tagged |
CNY 11,970.00 |
|
| RG207017 | RBL1 (tGFP-tagged) - Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 2 |
CNY 8,664.00 |
