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p107 (RBL1) (NM_183404) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC207017L3V
- LentiORF®
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Lenti ORF particles, RBL1 (Myc-DDK tagged) - Human retinoblastoma-like 1 (p107) (RBL1), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 11,210.00
| Cited in 2 publications. |
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CNY 2,950.00
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Product Name | p107 (RBL1) (NM_183404) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CP107; p107; PRB1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_183404 |
| ORF Size | 3042 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC207017).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_183404.1 |
| RefSeq Size | 3305 bp |
| RefSeq ORF | 3045 bp |
| Locus ID | 5933 |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Cell cycle, TGF-beta signaling pathway |
| MW | 114.7 kDa |
| Gene Summary | The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Association between copy-number alteration of +20q, −14q and −18p and cross-sensitivity to tyrosine kinase inhibitors in clear-cell renal cell carcinoma
,null,
Cancer Cell International
,PubMed ID 33041663
[RBL1]
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Intra-cisterna magna delivery of an AAV vector with the GLUT1 promoter in a pig recapitulates the physiological expression of SLC2A1
,Nakamura, S;Osaka, H;Muramatsu, SI;Takino, N;Ito, M;Jimbo, EF;Watanabe, C;Hishikawa, S;Nakajima, T;Yamagata, T;,
Gene Ther
,PubMed ID 33077933
[RBL1]
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