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HDAC2 (NM_001527) Human Untagged Clone
CAT＃: SC110918
HDAC2 (untagged)-Human histone deacetylase 2 (HDAC2), transcript variant 1
CNY 5,488.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HD2; KDAC2; RPD3; YAF1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_001527 edited
GGCAGCAGCAGCAGCAGCAGCAGCAGGAGGAGGAGCCCGGTGGCGGCGGTGGCCGGGGAG CCCATGGCGTACAGTCAAGGAGGCGGCAAAAAAAAAGTCTGCTACTACTACGACGGTGAT ATTGGAAATTATTATTATGGACAGGGTCATCCCATGAAGCCTCATAGAATCCGCATGACC CATAACTTGCTGTTAAATTATGGCTTATACAGAAAAATGGAAATATATAGGCCCCATAAA GCCACTGCCGAAGAAATGACAAAATATCACAGTGATGAGTATATCAAATTTCTACGGTCA ATAAGACCAGATAACATGTCTGAGTATAGTAAGCAGATGCAGAGATTTAATGTTGGAGAA GATTGTCCAGTGTTTGATGGACTCTTTGAGTTTTGTCAGCTCTCAACTGGCGGTTCAGTT GCTGGAGCTGTGAAGTTAAACCGACAACAGACTGATATGGCTGTTAATTGGGCTGGAGGA TTACATCATGCTAAGAAATCAGAAGCATCAGGATTCTGTTACGTTAATGATATTGTGCTT GCCATCCTTGAATTACTAAAGTATCATCAGAGAGTCTTATATATTGATATAGATATTCAT CATGGTGATGGTGTTGAAGAAGCTTTTTATACAACAGATCGTGTAATGACGGTATCATTC CATAAATATGGGGAATACTTTCCTGGCACAGGAGACTTGAGGGATATTGGTGCTGGAAAA GGCAAATACTATGCTGTCAATTTTCCAATGAGAGATGGTATAGATGATGAGTCATATGGG CAGATATTTAAGCCTATTATCTCAAAGGTGATGGAGATGTATCAACCTAGTGCTGTGGTA TTACAGTGTGGTGCAGACTCATTATCTGGTGATAGACTGGGTTGTTTCAATCTAACAGTC AAAGGTCATGCTAAATGTGTAGAAGTTGTAAAAACTTTTAACTTACCATTACTGATGCTT GGAGGAGGTGGCTACACAATCCGTAATGTTGCTCGATGTTGGACATATGAGACTGCAGTT GCCCTTGATTGTGAGATTCCCAATGAGTTGCCATATAATGATTACTTTGAGTATTTTGGA CCAGACTTCAAACTGCATATTAGTCCTTCAAACATGACAAACCAGAACACTCCAGAATAT ATGGAAAAGATAAAACAGCGTTTGTTTGAAAATTTGCGCATGTTACCTCATGCACCTGGT GTCCAGATGCAAGCTATTCCAGAAGATGCTGTTCATGAAGACAGTGGAGATGAAGATGGA GAAGATCCAGACAAGAGAATTTCTATTCGAGCATCAGACAAGCGGATAGCTTGTGATGAA GAATTCTCAGATTCTGAGGATGAAGGAGAAGGAGGTCGAAGAAATGTGGCTGATCATAAG AAAGGAGCAAAGAAAGCTAGAATTGAAGAAGATAAGAAAGAAACAGAGGACAAAAAAACA GACGTTAAGGAAGAAGATAAATCCAAGGACAACAGTGGTGAAAAAACAGATACCAAAGGA ACCAAATCAGAACAGCTCAGCAACCCCTGAATTTGACAGTCTCACCAATTTCAGAAAATC ATTAAAAAGAAAATATTGAAAGGAAAATGTTTTCTTTTTGAAGACTTCTGGCTTCATTTT ATACTACTTTGGCATGGACTGTATTTATTTTCAAATGGCTTTTTCGTTTTTGTTTTTCTT GGCAAGTTTTATTGTGAGTTTTTCTAATTATGAAGCAAAATTTCTTTTCTCCACCATGCT TTATGTGATAGTATTTAAAATTGATGTGAGTTATTATGTCAAAAAAACTGATCTATTAAA GAAGTAATTGGCCTTTCTGAGCTGATTTTTCCATCTTTTGTAATTATCTTTATTAAAAAA TTGTACTTGGA |
| Restriction Sites | Please inquire |
| ACCN | NM_001527 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | no |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001527.1, NP_001518.1 |
| RefSeq Size | 1985 bp |
| RefSeq ORF | 1467 bp |
| Locus ID | 3066 |
| UniProt ID | Q92769 |
| Domains | Hist_deacetyl |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer |
| Gene Summary | This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma
,Kobayashi, T;Nakazono, K;Tokuda, M;Mashima, Y;Dynlacht, BD;Itoh, H;,
EMBO Rep
,PubMed ID 28028031
[HDAC2]
|
|
AIRE acetylation and deacetylation: effect on protein stability and transactivation activity
,Incani, F;Serra, M;Meloni, A;Cossu, C;Saba, L;Cabras, T;Messana, I;Rosatelli, M;,
J. Biomed. Sci.
,PubMed ID 25158603
[HDAC2]
|
|
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
,null,
Molecular Neurodegeneration
,PubMed ID 24160175
[HDAC2]
|
Documents
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Resources
Other Versions
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| RC224919L1 | Lenti ORF clone of Human histone deacetylase 2 (HDAC2), transcript variant 1, Myc-DDK-tagged |
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| RC224919L2 | Lenti ORF clone of Human histone deacetylase 2 (HDAC2), transcript variant 1, mGFP tagged |
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| RC224919L3 | Lenti ORF clone of Human histone deacetylase 2 (HDAC2), transcript variant 1, Myc-DDK-tagged |
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| RC224919L4 | Lenti ORF clone of Human histone deacetylase 2 (HDAC2), transcript variant 1, mGFP tagged |
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| RG224919 | HDAC2 (tGFP-tagged) - Human histone deacetylase 2 (HDAC2), transcript variant 1 |
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| SC317003 | HDAC2 (untagged)-Human histone deacetylase 2 (HDAC2), transcript variant 1 |
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| SC318000 | HDAC2 (untagged)-Human histone deacetylase 2 (HDAC2), transcript variant 1 |
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