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LDL Receptor (LDLR) (NM_000527) Human Untagged Clone
CAT＃: SC110941
LDLR (untagged)-Human low density lipoprotein receptor (LDLR), transcript variant 1
CNY 9,456.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FH; FHC; FHCL1; LDLCQ2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>SC110941 representing NM_000527.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCGGCCGCGAATTCGGCACCAGGGACACAGCAGGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGC TGCGAGCATGGGGCCCTGGGGCTGGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGAC TGCAGTGGGCGACAGATGCGAAAGAAACGAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTG GGTCTGCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGACGTGCTTGTCTGTCAC CTGCAAATCCGGGGACTTCAGCTGTGGGGGCCGTGTCAACCGCTGCATTCCTCAGTTCTGGAGGTGCGA TGGCCAAGTGGACTGCGACAACGGCTCAGACGAGCAAGGCTGTCCCCCCAAGACGTGCTCCCAGGACGA GTTTCGCTGCCACGATGGGAAGTGCATCTCTCGGCAGTTCGTCTGTGACTCAGACCGGGACTGCTTGGA CGGCTCAGACGAGGCCTCCTGCCCGGTGCTCACCTGTGGTCCCGCCAGCTTCCAGTGCAACAGCTCCAC CTGCATCCCCCAGCTGTGGGCCTGCGACAACGACCCCGACTGCGAAGATGGCTCGGATGAGTGGCCGCA GCGCTGTAGGGGTCTTTACGTGTTCCAAGGGGACAGTAGCCCCTGCTCGGCCTTCGAGTTCCACTGCCT AAGTGGCGAGTGCATCCACTCCAGCTGGCGCTGTGATGGTGGCCCCGACTGCAAGGACAAATCTGACGA GGAAAACTGCGCTGTGGCCACCTGTCGCCCTGACGAATTCCAGTGCTCTGATGGAAACTGCATCCATGG CAGCCGGCAGTGTGACCGGGAATATGACTGCAAGGACATGAGCGATGAAGTTGGCTGCGTTAATGTGAC ACTCTGCGAGGGACCCAACAAGTTCAAGTGTCACAGCGGCGAATGCATCACCCTGGACAAAGTCTGCAA CATGGCTAGAGACTGCCGGGACTGGTCAGATGAACCCATCAAAGAGTGCGGGACCAACGAATGCTTGGA CAACAACGGCGGCTGTTCCCACGTCTGCAATGACCTTAAGATCGGCTACGAGTGCCTGTGCCCCGACGG CTTCCAGCTGGTGGCCCAGCGAAGATGCGAAGATATCGATGAGTGTCAGGATCCCGACACCTGCAGCCA GCTCTGCGTGAACCTGGAGGGTGGCTACAAGTGCCAGTGTGAGGAAGGCTTCCAGCTGGACCCCCACAC GAAGGCCTGCAAGGCTGTGGGCTCCATCGCCTACCTCTTCTTCACCAACCGGCACGAGGTCAGGAAGAT GACGCTGGACCGGAGCGAGTACACCAGCCTCATCCCCAACCTGAGGAACGTGGTCGCTCTGGACACGGA GGTGGCCAGCAATAGAATCTACTGGTCTGACCTGTCCCAGAGAATGATCTGCAGCACCCAGCTTGACAG AGCCCACGGCGTCTCTTCCTATGACACCGTCATCAGCAGAGACATCCAGGCCCCCGACGGGCTGGCTGT GGACTGGATCCACAGCAACATCTACTGGACCGACTCTGTCCTGGGCACTGTCTCTGTTGCGGATACCAA GGGCGTGAAGAGGAAAACGTTATTCAGGGAGAACGGCTCCAAGCCAAGGGCCATCGTGGTGGATCCTGT TCATGGCTTCATGTACTGGACTGACTGGGGAACTCCCGCCAAGATCAAGAAAGGGGGCCTGAATGGTGT GGACATCTACTCGCTGGTGACTGAAAACATTCAGTGGCCCAATGGCATCACCCTAGATCTCCTCAGTGG CCGCCTCTACTGGGTTGACTCCAAACTTCACTCCATCTCAAGCATCGATGTCAACGGGGGCAACCGGAA GACCATCTTGGAGGATGAAAAGAGGCTGGCCCACCCCTTCTCCTTGGCCGTCTTTGAGGACAAAGTATT TTGGACAGATATCATCAACGAAGCCATTTTCAGTGCCAACCGCCTCACAGGTTCCGATGTCAACTTGTT GGCTGAAAACCTACTGTCCCCAGAGGATATGGTTCTCTTCCACAACCTCACCCAGCCAAGAGGAGTGAA CTGGTGTGAGAGGACCACCCTGAGCAATGGCGGCTGCCAGTATCTGTGCCTCCCTGCCCCGCAGATCAA CCCCCACTCGCCCAAGTTTACCTGCGCCTGCCCGGACGGCATGCTGCTGGCCAGGGACATGAGGAGCTG CCTCACAGAGGCTGAGGCTGCAGTGGCCACCCAGGAGACATCCACCGTCAGGCTAAAGGTCAGCTCCAC AGCCGTAAGGACACAGCACACAACCACCCGGCCTGTTCCCGACACCTCCCGGCTGCCTGGGGCCACCCC TGGGCTCACCACGGTGGAGATAGTGACAATGTCTCACCAAGCTCTGGGCGACGTTGCTGGCAGAGGAAA TGAGAAGAAGCCCAGTAGCGTGAGGGCTCTGTCCATTGTCCTCCCCATCGTGCTCCTCGTCTTCCTTTG CCTGGGGGTCTTCCTTCTATGGAAGAACTGGCGGCTTAAGAACATCAACAGCATCAACTTTGACAACCC CGTCTATCAGAAGACCACAGAGGATGAGGTCCACATTTGCCACAACCAGGACGGCTACAGCTACCCCTC GAGACAGATGGTCAGTCTGGAGGATGACGTGGCGTGAACATCTGCCTGGAGTCCCGTCCCTGCCCAGAA CCCTTCCTGAGACCTCGCCAGCCTTGTTTTATTCAAAGACAGAGAAGACCAAAGCATTGCCTGCCAGAG CTTTGTTTTATATATTTATTCATCTGGGAGGCAGAACAGGCTTCGGACAGTGCCCATGCAATGGCTTGG GTTGGGATTTTGGTTTCTTCCTTTCCTCGTGAAGGATAAGAGAAACAGGCCCGGGGGGACCAGGATGAC ACCTCCATTTCTCTCCAGGAAGTTTTGAGTTTCTCTCCACCGTGACACAATCCTCAAACATGGAAGATG AAAGGGCAGGGGATGTCAGGCCCAGAGAAGCAAGTGGCTTTCAACACACAACAGCAGATGGCACCAACG GGACCCCCTGGCCCTGCCTCATCCACCAATCTCTAAGCCAAACCCCTAAACTCAGGAGTCAACGTGTTT ACCTCTTCTATGCAAGCCTTGCTAGACAGCCAGGTTAGCCTTTGCCCTGTCACCCCCAAATCATGACCC ACCCAGTGTCTTTCGAGGTGGGTTTGTACCTTCCTTAAGCCAGGAAAGGGATTCATGGCGTCGGAAATG ATCTGGCTGAATCCGTGGTGGCACCGAGACCAAACTCATTCACCAAATGATGCCACTTCCCAGAGGCAG AGCCTGAGTCACCGGTCACCCTTAATATTTATTAAGTGCCTGAGACACCCGGTTACCTTGGCCGTGAGG ACACGTGGCCTGCACCCAGGTGTGGCTGTCAGGACACCAGCCTGGTGCCCGTCCTCCCGACCCCTACCC ACTTCCATTCCCGTGGTCTCCTTGCACTTTCTCAGTTCAGAGTTGTACACTGTGTACATTTGGCATTTG TGTTATTATTTTGCACTGTTTTCTGTCGTGTGTGTTGGGATGGGATCCCAGGCCAGGGAAAGCCCGTGT CAATGAATGCCGGGGACAGAGAGGGGCAGGTTGACCGGGACTTCAAAGCCGTGATCGTGAATATCGAGA ACTGCCATTGTCGTCTTTATGTCCGCCCACCTAGTGCTTCCACTTCTATGCAAATGCCTCCAAGCCATT CACTTCCCCAATCTTGTCGTTGATGGGTATGTGTTTAAAACATGCACGGTGAGGCCGGGCGCAGTGGCT CACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCATGAGGTCAGGAGATCGAGACCAT CCTGGCTAACAAGGTGAAACCCCGTCTCTAAAAATACAAAAAATTAGCCGGGCGCGGTGGCGGGCACCT GTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGTGTGAACCCGGGAAGCGGAGGTTGAAGTGA GCCGAGATTGCGCCACTGCAGTCCGCAGTCCGGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAA AAAAAAAAAAAACTCGACTCTAGATTGCGGCCGC >OriGene 5' read for NM_000527 unedited
CGGATTTTGGTATACGACTCACTATAGGGCGGCCCGCGATTCGGCACCAGGNACACAGCA GGTCGTGATCCGGGTCGGGACACTGCCTGGCAGAGGCTGCGAGCATGGGGCCCTGGGGCT GGAAATTGCGCTGGACCGTCGCCTTGCTCCTCGCCGCGGCGGGGACTGCAGTGGGCGACA GATGCGAAAGAAACGAGTTCCAGTGCCAAGACGGGAAATGCATCTCCTACAAGTGGGTCT GCGATGGCAGCGCTGAGTGCCAGGATGGCTCTGATGAGTCCCAGGAGACGTGCTTGTCTG TCACCTGCAAATCCGGGGACTTCAGCTGTGGGGGCCGTGTCAACCGCTGCATTCCTCAGT TCTGGAGGTGCGATGGCCAAGTGGACTGCGACAACGGCTCAGACGAGCAAGGCTGTCCCC CCAAGACGTGCTCCCAGGACGAGTTTCGCTGCCACGATGGGAAGTGCATCTCTCGGCAGT TCGTCTGTGACTCAGACCGGGACTGCTTGGACGGCTCAGACGAGGCCTCCTGCCCGGTGC TCACCTGTGGTCCCGCCAGCTTCCAGTGCAACAGCTCCACCTGCATCCCCCAGCTGTGGG CCTGCGACAACGACCCCGACTGCGAAGATGGCTCGGATGAGTGGCCGCAGCGCTTGTAGG GTCTTTTACGTGTTCCAAGGGGGACAGTAGCCCCTGCTCGGCCTTCGAGTTCCACTGCCT AAGTGGGCGAGTGCATCCACTCCAGCTGGCGCTGGGAAATGGTGGCCCCCGACTGGCAGG ACANATCTGACGAGGAACCTGGGGCTGTGGCCACCTGTCGCCTGACGAATCCAGTGCTCT GATGGGAACTGCATCATGGCGCCGGCAGTTGACCGGGATTTGACTGCCAGCTGGCCNCNN NAAATTTGCTGGCTTATGGACACTTTGGAGCCCACAAGTTCAGTGCCACGGGCGAAGG >OriGene 3' read for NM_000527 unedited
NNNTTAAGCTCTGNNACCGCGGCCGCATNCTAGNGTCGAGTTTTTTTTTTTTTTTTTTTT GAAACGGAGTCTCGCTCTGTCGCCCAGGCCGGACTGCGGACTGCAGTGGCGCAATCTCGG CTCACTTCAACCTCCGCTTCCCGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAG CTGGGACTACAGGTGCCCGCCACCGCGCCCGGCTAATTTTTTGTATTTTTAAGAGAACGG GGTTTCACCTTGTTAGCCAGGATGGGTCTCGATCTCCTGACCTCATGATCCACCCGGCTT TGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGGCCCCGGGCTCACCGTGCAT GGTTTAAACACATACCCATTAACGACCAGATATGGGAAATGAATGGCTTTGAAGCATTTG GATANAAGTGGAAAACCTTAAGGGGGCGGGCATTAAGACCACAATGGGAGGTCTTCGAGA TTTACGAAAACCAGGTTTGAAAAACCCCGGGAAAACTGTCCCCTTTCTGTGCCCCGGGAT TTATTTGGAACAGGGTTTTTCCTGGGCCGGGGATCCCCTCCCCACACCCCCCACCGGAAA AAGCGGCCAAAAAAAACACCAAAGGCCAAAGGGCCCAATGGGCCACTTCTTTACCTCGAA AAGGCCAGGGGACCCCCGGAATGGAAAAGGGTTAGGGGCCGGAAGAACGGGCCCAAACTG GGGGTCTTCAAAACCACCTGGGGGGAGGCCCCCTGTCCTCCCGGGCAAGGGAACCGGGGG TTCATGCCCCTTTTAAAAATTAGGGGGGACCGGGGCTCCAGCCTTTCTCCTGGGAAAAGG GCCATTTTGGGAAAAAAGATTGGTTCCGGGCCCCCCCGGTTTTCCCGAGAATTTTCCCGG CCGGGAACCCTTCCCGGGTTAAGGAAGGCCAACCCCCCTTGAAGAACTGGNTGGTCAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000527 |
| Insert Size | 4105 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000527.2 |
| RefSeq Size | 5175 bp |
| RefSeq ORF | 4105 bp |
| Locus ID | 3949 |
| UniProt ID | P01130 |
| Domains | ldl_recept_b, EGF_CA, ldl_recept_a, EGF, EGF |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Endocytosis |
| MW | 153.3 kDa |
| Gene Summary | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Trypanosoma cruzi infection results in an increase in intracellular cholesterol
,Johndrow, C;Nelson, R;Tanowitz, H;Weiss, L;Nagajyothi, F;,
Microbes Infect., Feb 2014.
,PubMed ID 24486184
[LDLR]
|
|
The Role of Cholesterol Pathways in Norovirus Replication
,Kyeong-Ok Chang,
J. Virol., Jun 2009; 10.1128/JVI.00005-09.
[LDLR]
|
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Resources
Other Versions
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| RC200006L2 | Lenti ORF clone of Human low density lipoprotein receptor (LDLR), transcript variant 1, mGFP tagged |
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| RC200006L3 | Lenti ORF clone of Human low density lipoprotein receptor (LDLR), transcript variant 1, Myc-DDK-tagged |
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| RC200006L4 | Lenti ORF clone of Human low density lipoprotein receptor (LDLR), transcript variant 1, mGFP tagged |
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| RG200006 | LDLR (tGFP-tagged) - Human low density lipoprotein receptor (LDLR), transcript variant 1 |
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