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PTP1B (PTPN1) (NM_002827) Human Untagged Clone
CAT＃: SC110989
PTPN1 (untagged)-Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1)
CNY 3,656.00
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | PTP1B |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC110989 sequence for NM_002827 edited (data generated by NextGen Sequencing)
ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTAC CAGGATATCCGACATGAAGCCAGTGACTTCCCATGTAGAGTGGCCAAGCTTCCTAAGAAC AAAAACCGAAATAGGTACAGAGACGTCAGTCCCTTTGACCATAGTCGGATTAAACTACAT CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGT TACATTCTTACCCAGGGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGG GAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCGTTAAAA TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTG AAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTG GAAAACCTTACAACCCAAGAAACTCGAGAGATCTTACATTTCCACTATACCACATGGCCT GACTTTGGAGTCCCTGAATCACCAGCCTCATTCTTGAACTTTCTTTTCAAAGTCCGAGAG TCAGGGTCACTCAGCCCGGAGCACGGGCCCGTTGTGGTGCACTGCAGTGCAGGCATCGGC AGGTCTGGAACCTTCTGTCTGGCTGATACCTGCCTCTTGCTGATGGACAAGAGGAAAGAC CCTTCTTCCGTTGATATCAAGAAAGTGCTGTTAGAAATGAGGAAGTTTCGGATGGGGCTG ATCCAGACAGCCGACCAGCTGCGCTTCTCCTACCTGGCTGTGATCGAAGGTGCCAAATTC ATCATGGGGGACTCTTCCGTGCAGGATCAGTGGAAGGAGCTTTCCCACGAGGACCTGGAG CCCCCACCCGAGCATATCCCCCCACCTCCCCGGCCACCCAAACGAATCCTGGAGCCACAC AATGGGAAATGCAGGGAGTTCTTCCCAAATCACCAGTGGGTGAAGGAAGAGACCCAGGAG GATAAAGACTGCCCCATCAAGGAAGAAAAAGGAAGCCCCTTAAATGCCGCACCCTACGGC ATCGAAAGCATGAGTCAAGACACTGAAGTTAGAAGTCGGGTCGTGGGGGGAAGTCTTCGA GGTGCCCAGGCTGCCTCCCCAGCCAAAGGGGAGCCGTCACTGCCCGAGAAGGACGAGGAC CATGCACTGAGTTACTGGAAGCCCTTCCTGGTCAACATGTGCGTGGCTACGGTCCTCACG GCCGGCGCTTACCTCTGCTACAGGTTCCTGTTCAACAGCAACACATAG Clone variation with respect to NM_002827.2 >OriGene 5' read for NM_002827 unedited
AGGGCGGCCGCGAATTCGGCACGAGGGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGG ATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTATAGCGGCAGACGGCGCAGTG GGCCGAGAAGGAGGCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGA GCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGATATCCGACATGAAGCCAG TGACTTCCCATGTAGAGTGGCCAAGCTTCCTAAGAACAAAAACCGAAATAGGTACAGAGA CGTCAGTCCCTTTGACCATAGTCGGATTAAACTACATCAAGAAGATAATGACTATATCAA CGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGTTACATTCTTACCCAGGGCCCTTT GCCTAACACATGCGGTCACTTTTGGGAGATGNGTGTGGGAGCAGAAAGCANGGGGTGTCG TCATGCTCAACAGAGTGATGGAGAANAGGGTTCGTTAAAATGCGCACAATACTGGCCACA AAAAGAAGAAAAGAGATGATCTTTGAAGACACAAATTTGAAATTAACATTGATCTCTGGA GATATCAAGTCATATTATACAGTGCGACAGCTAGAATTGGAAAACCTTTACACCCAAGAA CTCGAGAGATCTTACATTTCACTATACCACATGGCCTGCTTTTTGGAGTCCCTGAATACC AGCCTCATTCTTGAACTTTCTTTTACAAGTCCGAGAGTCAGGGTCACTCANCCCGGACCC GGGCCCCCTTNGTGGTGCCCTGNAATGCAAGCCTTCGGAAGGGCTGGGACCCTTTTGGCT GGGCGGATCCCTGCCTTTTGGTGAAGGACAAAAAGGAAGACCCTTCTTTCCGTGAATTAA AAAAAGGGCTGGTAAAAAAAGGGAGAATTCGCGATGGGGGCC >OriGene 3' read for NM_002827 unedited
AGCTATGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTAGAAAAA ATTTTATTGTTGCAGCTAAAATGCAAACCCATCATGAATATGGCAAGTTGGAAAACTGTA CAGTCTGACAGTTCTGTGAGGTCACAGAAGACCCTGAGACACTCCCCCCCACCCACCCGG TCATGCAGCCACGTATCCACACACACCTGAAAAGGTATTATACCAAAACACCTTGCTTTT TTTGTTTTTATTTTTGTAAAAATGGTTTATTCCATGGCCATTGTAAAAAATAATGACCTG ATGAGTAAATATTGGCTTAAGGCATATAGCAGAGCAGCTCGCTACCTCTCTAACATAATG TGTAACAAGGTGGAGAGCCAGCTGCTCTCCAAGGATAGGAGGTTAAACCAGTACGTCCAT TTTGAAATGCTACTATATATACACACCCAAACTACTACATACATATACAGGACTTAAAAA CAACAAGCCCAGCTCAGAATGCTTACAGCCTGGCACCTAAGCCTTATCCACACCTCACCA TAGCTCTGCAGGGTGACACCTCGAATGTTCCCACCACAGAATTTCTCTGTACTGGCTTCT ACCACGAGAAAGGCAAAATGTGAAAATGCTGGCAAGAGAGTAGCTCGGGAGCTACAGCTG CCGTGTTTTTCATGTTAAAAAGCCACTTAATGTGGAGGTCTTCAGTTCCCTTTGCAGGAA GAGTCGTGAGCACCATCAGGCCCCACAGGGTTTGAGGGTGGGGCAGACGCGCCTCTCTCG GNCAGGTGACCGGGACAGAGACGGCGGCAGGCTGCCTAAAGGACCGTCACCCAGNCTGTT TCAAGAAGTGTGNTTTCCAGCAGGTGCCCTCTCTTCCAATCACGGTCTGCTCAAGAGAAG GTTGACTTGGAATGGCGGAGGCTGATCCACAAGTTGGGGGCGGGGGGTGTCCCTGCTTCC TAAATATGTCCAGACGGA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002827 |
| Insert Size | 3520 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002827.2, NP_002818.1 |
| RefSeq Size | 3318 bp |
| RefSeq ORF | 1308 bp |
| Locus ID | 5770 |
| UniProt ID | P18031 |
| Domains | Y_phosphatase, PTPc_motif |
| Protein Families | Druggable Genome, Phosphatase, Transmembrane |
| Protein Pathways | Adherens junction, Insulin signaling pathway |
| Gene Summary | The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204902 | PTPN1 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1) |
CNY 3,656.00 |
|
| RC204902L1 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC204902L2 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1), mGFP tagged |
CNY 5,890.00 |
|
| RC204902L3 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC204902L4 | Lenti ORF clone of Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1), mGFP tagged |
CNY 6,056.00 |
|
| RG204902 | PTPN1 (tGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 1 (PTPN1) |
CNY 5,256.00 |
