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TIMP2 (NM_003255) Human Untagged Clone
CAT＃: SC118083
TIMP2 (untagged)-Human TIMP metallopeptidase inhibitor 2 (TIMP2)
CNY 2,400.00
CNY 2,950.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CSC-21K; DDC8 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_003255, the custom clone sequence may differ by one or more nucleotides
ATGGGCGCCGCGGCCCGCACCCTGCGGCTGGCGCTCGGCCTCCTGCTGCTGGCGACGCTGCTTCGCCCGG CCGACGCCTGCAGCTGCTCCCCGGTGCACCCGCAACAGGCGTTTTGCAATGCAGATGTAGTGATCAGGGC CAAAGCGGTCAGTGAGAAGGAAGTGGACTCTGGAAACGACATTTATGGCAACCCTATCAAGAGGATCCAG TATGAGATCAAGCAGATAAAGATGTTCAAAGGGCCTGAGAAGGATATAGAGTTTATCTACACGGCCCCCT CCTCGGCAGTGTGTGGGGTCTCGCTGGACGTTGGAGGAAAGAAGGAATATCTCATTGCAGGAAAGGCCGA GGGGGACGGCAAGATGCACATCACCCTCTGTGACTTCATCGTGCCCTGGGACACCCTGAGCACCACCCAG AAGAAGAGCCTGAACCACAGGTACCAGATGGGCTGCGAGTGCAAGATCACGCGCTGCCCCATGATCCCGT GCTACATCTCCTCCCCGGACGAGTGCCTCTGGATGGACTGGGTCACAGAGAAGAACATCAACGGGCACCA GGCCAAGTTCTTCGCCTGCATCAAGAGAAGTGACGGCTCCTGTGCGTGGTACCGCGGCGCGGCGCCCCCC AAGCAGGAGTTTCTCGACATCGAGGACCCATAA >OriGene 5' read for NM_003255 unedited
ATAGGGCGGGCCGCGATTCGGCACGAGGGGTAGGAGAGTAAGTTTGCGCGGCCGAGCGGG GCAGGTGAGGAGGGTGAGCCGCGCGGGAGGGGCCCGCCTCGGCCCCGGCTCAGCCCCCGC CCGCGCCCCCAGCCCGCCGCCGCGAGCAGCGCCCGGACCCCCCACGGCGGCCCCCGCCCG CCCAGCCCCCCGGCCCGCCATGGGCGCCGCGGCCCGCACCCTGCGGCTGGCGCTCGGCCT CCTGCTGCTGGCGACGCTGCTTCGCCCGGCCGACGCCTGCAGCTGCTCCCCGGTGCACCC GCAACAGGCGTTTTGCAATGCAGATGTAGTGATCAGGGCCAAAGCGGTCAGTGAGAAGGA AGTGGACTCTGGAAACGACATTTATGGCAACCCTATCAAGAGGATCCAGTATGAGATCAA GCAGATAAAGATGTTCAAAGGGCCTGAGAAGGATATAGAGTTTATCTACACGGCCCCCTC CTCGGCAGTGTGTGGGGTCTCACTGGACGTTGGAGGAAAGAAGGAATATCTCATTGCAGG AAAGGCCGAGGGGGACGGCAAGATGCACATCACCCTCTGTGACTTCATCGTGCCCTGGGA CACCCTGAGCACCACCCAGAAGAAGAGCCTGAACCACAGGTACCAGATGGGCTGCGAGTG CAAGATCACGCGCTGCCCCATGATCCCGTGCTACATCTCCTCCCCGGACGAGTGCCTCNT GGATGGACTGGGGTCACAGAGAGAACATTAACGGGCACCAAGCCAAGTTTCTCGCCTGCA TAAAGAGAAGTGACGGGCTCTGTGCGTGGTACCGGGGGGCGCGGCCCCCAAGCAGGAGGT TCTGGACATCGAGACCCATAAGCAGGCCTCCCACGCCCCTGGGGGCAACTGCAAAAAACC CTCCAGGGTTTCGACTGGNCAGCTCTA >OriGene 3' read for NM_003255 unedited
AATTCTCATGNCGCGCGGCCCGCAGTTCTAGCGATCNGCCTTTTTTTTTTTTTTTTTTTC TCTTTGAAATACTGTTTATTGTCCACGGACCGAGCGATTGCTCAAGAATGATACAAAGCA TCAGAGACATGCGCAGTCTGCTTGACAACTTTCAACAACTCTTGTGTGTTCCCAGCACCG GAAGGTCTCAAACTTCATATTCCAGCATAAACACAGTGCTCCCCTCCCCCAAAAATCCAA ACGGAAACAAAATCAACAGAGCTTTAAATTACGGCAGCAAGTCCAATATTTCTTAATACT TATCAAGCAAAGATTTGAAAATAACTACAATGTAAACTTTATTTTAAATATTTTGAGTTG CTTGCAGGATGAAAATAGGAGAAGAGAGCTGTGCTTAGAACATAACATATAAATTAAACG ATGCCAAATGGAGAGCCTTCTTAAACTACATATATATTGCCACTATTTATTGTGAAGGTA TTTGAGCGGCTTCCTCTGTCAGCTGCCACCCGGCTCTTCTTAACCTGTTTTGTTTTCTGC TCACCACGGTTAAAAGACCAACGTGTGTGGATCAAATATAAAGGCCACACCTTTCAGACC GAACCTACTCAAAGATCCTTTACTTTGCAATAATTTGAACTGGAGAACCAAAGACGGGAG ACGAATGCAAGCAAAGATGCTCAAAGAACCAAAGGAAAGCACCTGAGGAATCCACCTGCA TAGGCCACGCGTTCCACTCCTGGTCAAATGCTTTCACGATGCAGAAACCCTTTTTTAAAA AGGGCAAGCCTAATACCTACCAGGGTATTAAAAAACCCGCCCAGGGATGGATACCGCTGA TGTCAAAACCAAACCAAAACTTTAAAAACCATCCGCCGAAAAAGAGTAAATGGTCCTATT GTCTCCCCTACAGGACCGAACAGGTGGGGTATGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003255 |
| Insert Size | 3630 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003255.4, NP_003246.1 |
| RefSeq Size | 3670 bp |
| RefSeq ORF | 663 bp |
| Locus ID | 7077 |
| UniProt ID | P16035 |
| Domains | NTR |
| Protein Families | Druggable Genome, Secreted Protein |
| Gene Summary | This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells
,Cepeda, MA;Pelling, JJ;Evered, CL;Williams, KC;Freedman, Z;Stan, I;Willson, JA;Leong, HS;Damjanovski, S;,
Mol. Cancer
,PubMed ID 27756325
[TIMP2]
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Resources
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