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LOX 1 (OLR1) (NM_002543) Human Untagged Clone
CAT＃: SC118589
OLR1 (untagged)-Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1
CNY 2,400.00
CNY 6,270.00
| Cited in 7 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CLEC8A; LOX1; LOXIN; SCARE1; SLOX1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC118589 sequence for NM_002543 edited (data generated by NextGen Sequencing)
ATGACTTTTGATGACCTAAAGATCCAGACTGTGAAGGACCAGCCTGATGAGAAGTCAAAT GGAAAAAAAGCTAAAGGTCTTCAGTTTCTTTACTCTCCATGGTGGTGCCTGGCTGCTGCG ACTCTAGGGGTCCTTTGCCTGGGATTAGTAGTGACCATTATGGTGCTGGGCATGCAATTA TCCCAGGTGTCTGACCTCCTAACACAAGAGCAAGCAAACCTAACTCACCAGAAAAAGAAA CTGGAGGGACAGATCTCAGCCCGGCAACAAGCAGAAGAAGCTTCACAGGAGTCAGAAAAC GAACTCAAGGAAATGATAGAAACCCTTGCTCGGAAGCTGAATGAGAAATCCAAAGAGCAA ATGGAACTTCACCACCAGAATCTGAATCTCCAAGAAACACTGAAGAGAGTAGCAAATTGT TCAGCTCCTTGTCCGCAAGACTGGATCTGGCATGGAGAAAACTGTTACCTATTTTCCTCG GGCTCATTTAACTGGGAAAAGAGCCAAGAGAAGTGCTTGTCTTTGGATGCCAAGTTGCTG AAAATTAATAGCACAGCTGATCTGGACTTCATCCAGCAAGCAATTTCCTATTCCAGTTTT CCATTCTGGATGGGGCTGTCTCGGAGGAACCCCAGCTACCCATGGCTCTGGGAGGACGGT TCTCCTTTGATGCCCCACTTATTTAGAGTCCGAGGCGCTGTCTCCCAGACATACCCTTCA GGTACCTGTGCATATATACAACGAGGAGCTGTTTATGCGGAAAACTGCATTTTAGCTGCC TTCAGTATATGTCAGAAGAAGGCAAACCTAAGAGCACAGTGA Clone variation with respect to NM_002543.3 >OriGene 5' read for NM_002543 unedited
NGTTCGGGATTTTGTAATACGACTTACTATAGGCGGCCGCGNAATTCGCACGAGGCTGCT TCACTCTCTCATTCTTAGCTTGAATTTGGAAATGACTTTTGATGACCTAAAGATCCAGAC TGTGAAGGACCAGCCTGATGAGAAGTCAAATGGGAAAAAAAGCTAAAGGTCTTCAGTTTC TTTACTCTCCATGGTGGTGCCTGGCTGCTGCGACTCTAGGGGTCCTTTGCCTGGGATTAG TAGTGACCATTATGGTGCTGGGCATGCAATTATCCCAGGTGTCTGACCTCCTAACACAAG AGCAAGCAAACCTAACTCACCAGAAAAAGAAACTGGAGGGACAGATCTCAGCCCGGCAAC AAGCAGAAGAAGCTTCACAGGAGTCAGAAAACGAACTCAAGGAAATGATAGAAACCCTTG CTCGGAAGCTGAATGAGAAATCCAAAGAGCAAATGGAACTTCACCACCAGAATCTGAATC TCCAAGAAACACTGAAGAGAGTAGCAAATTGTTCAGCTCCTTGTCCGCAAGACTGGATCT GGCATGGAGAAAACTGTTACCTATTTTCCTCGGGCTCATTTAACTGGGAAAAGAGCCAAG AGAAGTGCTTGTCTTTGGATGCCAAGTTGCTGAAAATTAATAGCACAGCTGATCTGGACT TCATCCAGCAAGCAATTTCCTATTCCAGTTTTCCATTCTGGATGGGGCTGTCTCGGAGGA ACCCCAGCTACCCATGGCTCTGGGAGGACGGTTCTCCTTTGATGCCCCACTTATTAGAGT CCGAGGCGCTGTCTNCCCAAAATACCCTTCAGGTACCTGTGCATATATACAACGAGGAGC TGTTTATGCCGAAAACTGCCATTTAGCTGCCTTCAGTATATGTCAGAAAGAGGCNANACC TAGNAGCCCAGTGATTT >OriGene 3' read for NM_002543 unedited
ACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTGGACCCAAATGTTCACAACAGCTTTTTTTGTAATATCCCAAAACTAA AACAACCCCAATGTCCTCAACAAGTAAATGGGGAAAAGAATTGGGGGTTTTCCCTACCAG GGAATATTCAACATTTAAAAAAATGAATTCCTTCCACCCTTAAAATGGGGACCTTTGAAT CTCAAAATAATTATGCCAAGGGAAAAAAGCCCCACCAAAAAAAAAAACCTTCTTTTTGAT TCCCTTCCCCTAAAACTTCCAAATGCCAAATGAAAGCCCATTGGGGGGTTTTTGGGGGGG AGTCCTCAGGAGGAGCCTTGGGACCCTTTGAGGGATGAAGGATATGTTCACTCTCTTAAT TGGAGGATGCATGTTCTCCACAAGGGGGGAAAACTTATCAAATAGTACACTTTAAATATG TTCAGGTTATTTTATGGTAATTATATCTCAATAAAGCTTTTAACAAAAGCAAACATTTTT TGCCTACATAAGGATGACACAACTCTTAAAAAAAAAAAAAAAATTTCTGCTATATTGGGT GCACCAAAATAAAAAGGGTTCCCTTAAAGTAAAAAACCCCGTGGAGAATGGGTGGAAAGG AATAAAAACCCTAAAAATAAAAAAAATATTTCTAAATCCCTCTGGTTTTTATTAACCGAA TTTGCCTACCTGCCTCAATTTGTCTAAAAGGAGGGCCTCCTTTTTTTTTGCCTGGAAGGT GCCGAATTTTACCTACCCAACCAAGTTGGAAAATCTCTTCTCCAAGGTGTTTTTTTTAGG GAAAAAATTTATTTTACCTTTGGGCCCACATCCATGTTTTAACAAAATGTGGGAAGGGGT AAACCTTAAATTGCCCTCGGAGAAAAAAAAGAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002543 |
| Insert Size | 2600 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002543.2, NP_002534.1 |
| RefSeq Size | 2476 bp |
| RefSeq ORF | 822 bp |
| Locus ID | 4973 |
| UniProt ID | P78380 |
| Domains | CLECT |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | PPAR signaling pathway |
| Gene Summary | This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
Citations (7)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Picroside II attenuates hyperhomocysteinemia-induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis
,Wang, Y;Hong, Y;Zhang, C;Shen, Y;Pan, YS;Chen, RZ;Zhang, Q;Chen, YH;,
J. Cell. Mol. Med.
,PubMed ID 30394648
[OLR1]
|
|
High-Density Lipoprotein Prevents Endoplasmic Reticulum Stress-Induced Downregulation of Liver LOX-1 Expression
,Hong, D;Li, LF;Gao, HC;Wang, X;Li, CC;Luo, Y;Bai, YP;Zhang, GG;,
PLoS ONE
,PubMed ID 25923692
[OLR1]
|
|
Prevention of export of anoxia/reoxygenation injury from ischemic to non-ischemic cardiomyocytes via inhibition of endocytosis
,Khaidakov, M;Mercanti, F;Wang, X;Ding, Z;Dai, Y;Romeo, F;Sawamura, T;Mehta, JL;,
Am. J. Physiol. Heart Circ. Physiol. April 2014
,PubMed ID 24778168
[OLR1]
|
|
LOX-1-dependent transcriptional regulation in response to oxidized LDL treatment of human aortic endothelial cells.
,null,
American journal of physiology. Cell physiology
,PubMed ID 19279231
[OLR1]
|
|
LOX-1-dependent transcriptional regulation in response to oxidized LDL treatment of human aortic endothelial cells
,Mark D. Mattaliano, Christine Huard, Wei Cao, Andrew A. Hill, Wenyan Zhong, Robert V. Martinez, Doug C. Harnish, Janet E. Paulsen, and Heather H. Shih,
Am J Physiol Cell Physiol, Jun 2009; 296: C1329 - C1337.
[OLR1]
|
|
CRP is a novel ligand for the oxidized LDL receptor LOX-1
,Heather H. Shih, Songwen Zhang, Wei Cao, Ashleigh Hahn, Juan Wang, Janet E. Paulsen, and Douglas C. Harnish,
Am J Physiol Heart Circ Physiol, May 2009; 296: H1643 - H1650.
[OLR1]
|
|
CRP is a novel ligand for the oxidized LDL receptor, LOX-1
,Heather H Shih, Songwen Zhang, Wei Cao, Ashleigh Hahn, Juan Wang, Janet E Paulsen, and Douglas C Harnish,
Am J Physiol Heart Circ Physiol, Feb 2009; 10.1152/ajpheart.00938.2008.
[OLR1]
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Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC204704 | OLR1 (Myc-DDK-tagged)-Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1 |
CNY 2,400.00 |
|
| RC204704L1 | Lenti ORF clone of Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC204704L2 | Lenti ORF clone of Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1, mGFP tagged |
CNY 4,800.00 |
|
| RC204704L3 | Lenti ORF clone of Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC204704L4 | Lenti ORF clone of Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1, mGFP tagged |
CNY 4,800.00 |
|
| RG204704 | OLR1 (tGFP-tagged) - Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1 |
CNY 4,000.00 |
|
| SC321097 | OLR1 (untagged)-Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1 |
CNY 2,400.00 |
