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MASP1 (NM_139125) Human Untagged Clone
CAT＃: SC120698
MASP1 (untagged)-Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 2
CNY 5,344.00
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | 3MC1; CRARF; CRARF1; MAP-1; MAP1; MAp44; MASP; MASP-3; MASP3; PRSS5; RaRF |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_139125, the custom clone sequence may differ by one or more nucleotides
ATGAGGTGGCTGCTTCTCTATTATGCTCTGTGCTTCTCCCTGTCAAAGGCTTCAGCCCACACCGTGGAGC TAAACAATATGTTTGGCCAGATCCAGTCGCCTGGTTATCCAGACTCCTATCCCAGTGATTCAGAGGTGAC TTGGAATATCACTGTCCCAGATGGGTTTCGGATCAAGCTTTACTTCATGCACTTCAACTTGGAATCCTCC TACCTTTGTGAATATGACTATGTGAAGGTAGAAACTGAGGACCAGGTGCTGGCAACCTTCTGTGGCAGGG AGACCACAGACACAGAGCAGACTCCCGGCCAGGAGGTGGTCCTCTCCCCTGGCTCCTTCATGTCCATCAC TTTCCGGTCAGATTTCTCCAATGAGGAGCGTTTCACAGGCTTTGATGCCCACTACATGGCTGTGGATGTG GACGAGTGCAAGGAGAGGGAGGACGAGGAGCTGTCCTGTGACCACTACTGCCACAACTACATTGGCGGCT ACTACTGCTCCTGCCGCTTCGGCTACATCCTCCACACAGACAACAGGACCTGCCGAGTGGAGTGCAGTGA CAACCTCTTCACTCAAAGGACTGGGGTGATCACCAGCCCTGACTTCCCAAACCCTTACCCCAAGAGCTCT GAATGCCTGTATACCATCGAGCTGGAGGAGGGTTTCATGGTCAACCTGCAGTTTGAGGACATATTTGACA TTGAGGACCATCCTGAGGTGCCCTGCCCCTATGACTACATCAAGATCAAAGTTGGTCCAAAAGTTTTGGG GCCTTTCTGTGGAGAGAAAGCCCCAGAACCCATCAGCACCCAGAGCCACAGTGTCCTGATCCTGTTCCAT AGTGACAACTCGGGAGAGAACCGGGGCTGGAGGCTCTCATACAGGGCTGCAGGAAATGAGTGCCCAGAGC TACAGCCTCCTGTCCATGGGAAAATCGAGCCCTCCCAAGCCAAGTATTTCTTCAAAGACCAAGTGCTCGT CAGCTGTGACACAGGCTACAAAGTGCTGAAGGATAATGTGGAGATGGACACATTCCAGATTGAGTGTCTG AAGGATGGGACGTGGAGTAACAAGATTCCCACCTGTAAAATTGTAGACTGTAGAGCCCCAGGAGAGCTGG AACACGGGCTGATCACCTTCTCTACAAGGAACAACCTCACCACATACAAGTCTGAGATCAAATACTCCTG TCAGGAGCCCTATTACAAGATGCTCAACAATAACACAGGTATATATACCTGTTCTGCCCAAGGAGTCTGG ATGAATAAAGTATTGGGGAGAAGCCTACCCACCTGCCTTCCAGAGTGTGGTCAGCCCTCCCGCTCCCTGC CAAGCCTGGTCAAGAGGATCATTGGGGGCCGAAATGCTGAGCCTGGCCTCTTCCCGTGGCAGGCCCTGAT AGTGGTGGAGGACACTTCGAGAGTGCCAAATGACAAGTGGTTTGGGAGTGGGGCCCTGCTCTCTGCGTCC TGGATCCTCACAGCAGCTCATGTGCTGCGCTCCCAGCGTAGAGACACCACGGTGATACCAGTCTCCAAGG AGCATGTCACCGTCTACCTGGGCTTGCATGATGTGCGAGACAAATCGGGGGCAGTCAACAGCTCAGCTGC CCGAGTGGTGCTCCACCCAGACTTCAACATCCAAAACTACAACCACGATATAGCTCTGGTGCAGCTGCAG GAGCCTGTGCCCCTGGGACCCCACGTTATGCCTGTCTGCCTGCCAAGGCTTGAGCCTGAAGGCCCGGCCC CCCACATGCTGGGCCTGGTGGCCGGCTGGGGCATCTCCAATCCCAATGTGACAGTGGATGAGATCATCAG CAGTGGCACACGGACCTTGTCAGATGTCCTGCAGTATGTCAAGTTACCCGTGGTGCCTCACGCTGAGTGC AAAACTAGCTATGAGTCCCGCTCGGGCAATTACAGCGTCACGGAGAACATGTTCTGTGCTGGCTACTACG AGGGCGGCAAAGACACGTGCCTTGGAGATAGCGGTGGGGCCTTTGTCATCTTTGATGACTTGAGCCAGCG CTGGGTGGTGCAAGGCCTGGTGTCCTGGGGGGGACCTGAAGAATGCGGCAGCAAGCAGGTCTATGGAGTC TACACAAAGGTCTCCAATTACGTGGACTGGGTGTGGGAGCAGATGGGCTTACCACAAAGTGTTGTGGAGC CCCAGGTGGAACGGTGA >OriGene 5' read for NM_139125 unedited
GGTGCAAATTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGGCAA GTCAAGCTGGGAGGACCAAGGCCGGGCAGCCGGGAGCACCCAAGGCAGGAAAATGAGGTG GCTGCTTCTCTATTATGCTCTGTGCTTCTCCCTGTCAAAGGCTTCAGCCCACACCGTGGA GCTAAACAATATGTTTGGCCAGATCCAGTCGCCTGGTTATCCAGACTCCTATCCCAGTGA TTCAGAGGTGACTTGGAATATCACTGTCCCAGATGGGTTTCGGATCAAGCTTTACTTCAT GCACTTCAACTTGGAATCCTCCTACCTTTGTGAATATGACTATGTGAAGGTAGAAACTGA GGACCAGGTGCTGGCAACCTTCTGTGGCAGGGAGACCACAGACACAGAGCAGACTCCCGG CCAGGAGGTGGTCCTCTCCCCTGGCTCCTTCATGTCCATCACTTTCCGGTCAGATTTCTC CAATGAGGAGCGTTTCACAGGCTTTGATGCCCACTACATGGCTGTGGATGTGGACGAGTG CAAGGAGAGGGAGGACGAGGAGCTGTCCTGTGACCACTACTGCCACAACTACATTGGCGG CTACTACTGCTCCTGCCGCTTCGGCTACATCCTCCACACAGACAACAGGACCTGCCGAGT GGAGTGCAGTGACAACCTCTTCACTCAAAGGACTGGNGTGATCACCAGCCCTGACTTCCA AACCCCTTACCCAGAGCTCTNGATGCCTGTATACCATCGAGCTGGAAGAAGGTTTCATGG TCAACCTGCAGTTTGAGGACATATTTGACATTGAGGACCCATCCTGAGTGCCCTGNCCCT ATGACTACATCAAGATCAAAGTTGGTTCCAAAAGTTTGGGGCCTTTCTGTTGAGAGAAGC CCCANAACCATCAGCCCCAGAGCCACAGTGTCCTGATCCTGTTCCATAAG >OriGene 3' read for NM_139125 unedited
NGGCCCTTGGTGATGGCACTCTCCGGTCCAGTAAAGCACTGGGGAAGGGGTCACAGGGCA TGCCACCCGGGCATCTGTTGCAGGAAAAGCTATGACCGCGGCCGCAATCTAAAGTCGAGT TTTTTTTTTTTTTTTTTTGTTGGTTATCCACGAGGGTATATTTCCACTTGAGACCCCTGA TGGGAGCAACAATGCAGAGGCCCTTTACATAATGGTGAAGCATATGATATAAAAGATACA AAATATAACATCATTTACATGTGCCATTCATAGACAAAGGAGTGTGTTTGATGAGCCCGT TGGAGAAGTGGACACTTCCCAATCATTCCCTCTCAGGGGCTTCTCTGGCTGCCTTGCTCT GATGGAGATTTTCAGGAGAGAGAGCTCCTGGGAGAAGGAGAACAATCAGCCCTGTGAGGG CCAAAGAGGCTGCTAGCAGTCAGGGAAGCTCTGAGTGCTCCAGCTAGAATGAACCTGCAG GGGACCTTATGCCAGCCTGTTGCTGACGGAGAACCCGAGACTCAGACAAAGAAAATGATT TTTCAAAGGTTATACAGCCAGTTGGGGGCAGAGCAAGGACTACAACCCAGGACTCCTGGC TATTTTCACTGCCTGCCATGGGTGAGCCTCTGATTCCTTTGACTCTGAAAAATGAAGGAG TGGGCCCCTCTGAACATCCTGCGGAGTGTATTCTCCGCCCATCTCATGCCCCAAGGATGC CAGGCAGCCTGTCAGGATTTGGGTGACTTCTAATGTGCCCACCCCACTCTTGCTTGCATT TTCCTGCCCAAAATCACACCTAGGACACAGGGTGAGTTCTTTTGCTTTTTCCAGGGAATC GACTAAGTCCCCATATTCGGGGCCTTGGACTC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_139125 |
| Insert Size | 3750 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_139125.2, NP_624302.1 |
| RefSeq Size | 4137 bp |
| RefSeq ORF | 2187 bp |
| Locus ID | 5648 |
| UniProt ID | P48740 |
| Domains | CCP, CUB, Tryp_SPc, EGF_CA |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | Complement and coagulation cascades |
| Gene Summary | This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1. This isoform (2) is referred to as MASP3 in the literature. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221839 | MASP1 (Myc-DDK-tagged)-Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 2 |
CNY 5,336.00 |
|
| RC221839L3 | Lenti ORF clone of Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC221839L4 | Lenti ORF clone of Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG221839 | MASP1 (tGFP-tagged) - Human mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1), transcript variant 2 |
CNY 6,936.00 |
