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IRS1 (NM_005544) Human Untagged Clone
CAT＃: SC124032
IRS1 (untagged)-Human insulin receptor substrate 1 (IRS1)
CNY 8,656.00
| Cited in 4 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HIRS-1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC124032 sequence for NM_005544 edited (data generated by NextGen Sequencing)
ATGGCGAGCCCTCCGGAGAGCGATGGCTTCTCGGACGTGCGCAAGGTGGGCTACCTGCGC AAACCCAAGAGCATGCACAAACGCTTCTTCGTACTGCGCGCGGCCAGCGAGGCTGGGGGC CCGGCGCGCCTCGAGTACTACGAGAACGAGAAGAAGTGGCGGCACAAGTCGAGCGCCCCC AAACGCTCGATCCCCCTTGAGAGCTGCTTCAACATCAACAAGCGGGCTGACTCCAAGAAC AAGCACCTGGTGGCTCTCTACACCCGGGACGAGCACTTTGCCATCGCGGCGGACAGCGAG GCCGAGCAAGACAGCTGGTACCAGGCTCTCCTACAGCTGCACAACCGTGCTAAGGGCCAC CACGACGGAGCTGCGGCCCTCGGGGCGGGAGGTGGTGGGGGCAGCTGCAGCGGCAGCTCC GGCCTTGGTGAGGCTGGGGAGGACTTGAGCTACGGTGACGTGCCCCCAGGACCCGCATTC AAAGAGGTCTGGCAAGTGATCCTGAAGCCCAAGGGCCTGGGTCAGACAAAGAACCTGATT GGTATCTACCGCCTTTGCCTGACCAGCAAGACCATCAGCTTCGTGAAGCTGAACTCGGAG GCAGCGGCCGTGGTGCTGCAGCTGATGAACATCAGGCGCTGTGGCCACTCGGAAAACTTC TTCTTCATCGAGGTGGGCCGTTCTGCCGTGACGGGGCCCGGGGAGTTCTGGATGCAGGTG GATGACTCTGTGGTGGCCCAGAACATGCACGAGACCATCCTGGAGGCCATGCGGGCCATG AGTGATGAGTTCCGCCCTCGCAGCAAGAGCCAGTCCTCGTCCAACTGCTCTAACCCCATC AGCGTCCCCCTGCGCCGGCACCATCTCAACAATCCCCCGCCCAGCCAGGTGGGGCTGACC CGCCGATCACGCACTGAGAGCATCACCGCCACCTCCCCGGCCAGCATGGTGGGCGGGAAG CCAGGCTCCTTCCGTGTCCGCGCCTCCAGTGACGGCGAAGGCACCATGTCCCGCCCAGCC TCGGTGGACGGCAGCCCTGTGAGTCCCAGCACCAACAGAACCCACGCCCACCGGCATCGG GGCAGCGCCCGGCTGCACCCCCCGCTCAACCACAGCCGCTCCATCCCCATGCCGGCTTCC CGCTGCTCGCCTTCGGCCACCAGCCCGGTCAGTCTGTCGTCCAGTAGCACCAGTGGCCAT GGCTCCACCTCGGATTGTCTCTTCCCACGGCGATCTAGTGCTTCGGTGTCTGGTTCCCCC AGCGATGGCGGTTTCATCTCCTCGGATGAGTATGGCTCCAGTCCCTGCGATTTCCGGAGT TCCTTCCGCAGTGTCACTCCGGATTCCCTGGGCCACACCCCACCAGCCCGCGGTGAGGAG GAGCTAAGCAACTATATCTGCATGGGTGGCAAGGGGCCCTCCACCCTGACCGCCCCCAAC GGTCACTACATTTTGTCTCGGGGTGGCAATGGCCACCGCTGCACCCCAGGAACAGGCTTG GGCACGAGTCCAGCCTTGGCTGGGGATGAAGCAGCCAGTGCTGCAGATCTGGATAATCGG TTCCGAAAGAGAACTCACTCGGCAGGCACATCCCCTACCATTACCCACCAGAAGACCCCG TCCCAGTCCTCAGTGGCTTCCATTGAGGAGTACACAGAGATGATGCCTGCCTACCCACCA GGAGGTGGCAGTGGAGGCCGACTGCCGGGACACAGGCACTCCGCCTTCGTGCCCACCCGC TCCTACCCAGAGGAGGGTCTGGAAATGCACCCCTTGGAGCGTCGGGGGGGGCACCACCGC CCAGACAGCTCCACCCTCCACACGGATGATGGCTACATGCCCATGTCCCCAGGGGTGGCC CCAGTGCCCAGTGGCCGAAAGGGCAGTGGAGACTATATGCCCATGAGCCCCAAGAGCGTA TCTGCCCCACAGCAGATCATCAATCCCATCAGACGCCATCCCCAGAGAGTGGACCCCAAT GGCTACATGATGATGTCCCCCAGCGGTGGCTGCTCTCCTGACATTGGAGGTGGCCCCAGC AGCAGCAGCAGCAGCAGCAACGCCGTCCCTTCCGGGACCAGCTATGGAAAGCTGTGGACA AACGGGGTAGGGGGCCACCACTCTCATGTCTTGCCTCACCCCAAACCCCCAGTGGAGAGC AGCGGTGGTAAGCTCTTACCTTGCACAGGTGACTACATGAACATGTCACCAGTGGGGGAC TCCAACACCAGCAGCCCCTCCGACTGCTACTACGGCCCTGAGGACCCCCAGCACAAGCCA GTCCTCTCCTACTACTCATTGCCAAGATCCTTTAAGCACACCCAGCGCCCCGGGGAGCCG GAGGAGGGTGCCCGGCATCAGCACCTCCGCCTTTCCACTAGCTCTGGTCGCCTTCTCTAT GCTGCAACAGCAGATGATTCTTCCTCTTCCACCAGCAGCGACAGCCTGGGTGGGGGATAC TGCGGGGCTAGGCTGGAGCCCAGCCTTCCACATCCCCACCATCAGGTTCTGCAGCCCCAT CTGCCTCGAAAGGTGGACACAGCTGCTCAGACCAATAGCCGCCTGGCCCGGCCCACGAGG CTGTCCCTGGGGGATCCCAAGGCCAGCACCTTACCTCGGGCCCGAGAGCAGCAGCAGCAG CAGCAGCCCTTGCTGCACCCTCCAGAGCCCAAGAGCCCGGGGGAATATGTCAATATTGAA TTTGGGAGTGATCAGTCTGGCTACTTGTCTGGCCCGGTGGCTTTCCACAGCTCACCTTCT GTCAGGTGTCCATCCCAGCTCCAGCCAGCTCCCAGAGAGGAAGAGACTGGCACTGAGGAG TACATGAAGATGGACCTGGGGCCGGGCCGGAGGGCAGCCTGGCAGGAGAGCACTGGGGTC GAGATGGGCAGACTGGGCCCTGCACCTCCCGGGGCTGCTAGCATTTGCAGGCCTACCCGG GCAGTGCCCAGCAGCCGGGGTGACTACATGACCATGCAGATGAGTTGTCCCCGTCAGAGC TACGTGGACACCTCGCCAGCTGCCCCTGTAAGCTATGCTGACATGCGAACAGGCATTGCT GCAGAGGAGGTGAGCCTGCCCAGGGCCACCATGGCTGCTGCCTCCTCATCCTCAGCAGCC TCTGCTTCCCCGACTGGGCCTCAAGGGGCAGCAGAGCTGGCTGCCCACTCGTCCCTGCTG GGGGGCCCACAAGGACCTGGGGGCATGAGCGCCTTCACCCGGGTGAACCTCAGTCCTAAC CGCAACCAGAGTGCCAAAGTGATCCGTGCAGACCCACAAGGGTGCCGGCGGAGGCATAGC TCCGAGACTTTCTCCTCAACACCCAGTGCCACCCGGGTGGGCAACACAGTGCCCTTTGGA GCGGGGGCAGCAGTAGGGGGCGGTGGCGGTAGCAGCAGCAGCAGCGAGGATGTGAAACGC CACAGCTCTGCTTCCTTTGAGAATGTGTGGCTGAGGCCTGGGGAGCTTGGGGGAGCCCCC AAGGAGCCAGCCAAACTGTGTGGGGCTGCTGGGGGTTTGGAGAATGGTCTTAACTACATA GACCTGGATTTGGTCAAGGACTTCAAACAGTGCCCTCAGGAGTGCACCCCTGAACCGCAG CCTCCCCCACCCCCACCCCCTCATCAACCCCTGGGCAGCGGTGAGAGCAGCTCCACCCGC CGCTCAAGTGAGGATTTAAGCGCCTATGCCAGCATCAGTTTCCAGAAGCAGCCAGAGGAC CGTCAGTAG Clone variation with respect to NM_005544.2 >OriGene 5' read for NM_005544 unedited
AGCCGTTCANAATTTGTATACGACTCACTATAGGCGGCCCGCGAATTCGCACGAGGTTTT TCGGAGCCTCCCTCTGCTCAGCGTTGGTGGTGGCGGTGGCAGCATGGCGAGCCCTCCGGA GAGCGATGGCTTCTCGGACGTGCGCAAGGTGGGCTACCTGCGCAAACCCAAGAGCATGCA CAAACGCTTCTTCGTACTGCGCGCGGCCAGCGAGGCTGGGGGCCCGGCGCGCCTCGAGTA CTACGAGAACGAGAAGAAGTGGCGGCACAAGTCGAGCGCCCCCAAACGCTCGATCCCCCT TGAGAGCTGCTTCAACATCAACAAGCGGGCTGACTCCAAGAACAAGCACCTGGTGGCTCT CTACACCCGGTACGAGCACTTTGCCATCGCGGCGGACAGCGTGGCCTAGCAAGACAGCTG GTACCAGGCTCTCCTACAGCTGCACAACCGTGCTAAGGGCCACCACGACGGAGCTGCGGC CCTCGGGGCGGGAGGTGGTGGGGGCAGCTGCAGCGGCAGAGTCCGGCCTTGGTGAGGCTG GGGAGGACTTGAGCTACGGTGACTTGCCCCCAGGACCCGCATTCAAAGAGGTCTGGCAAG TGATCCTGAAGCCCAAGGGCCTGGTTCAGACAAAGAACCTGATTGGTATCTACCGGTTTT GGCTGACCAGCAAGACCATCACCTTTCGGAACTTAACTTCGAGGCACCGGCCGTGGTGCC TCCACTGATGAACATTTGGCGCTGTGGCCACTCGGGAAAACTTTTCTTTCTCGAGGTGGG CCGTTCTGTCTTGACCGATCCCGGGGNATTCTTGCATCCAGGTGGGATGACTTTGTGGGG GCCCGTAAACTGCTGGAAACATCTTGGGGGGCCTGCTGGGCCATGA >OriGene 3' read for NM_005544 unedited
GGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGAAA CAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTCAACAG TATCTAGTTTATTATGAATAGAAAGACATTTCCAGAATTTACAAACGCCCACATTGTTCA TTCCAAAGAGAGCTTTTGAATTGAAGGAATCACCCATCTCCTTCTGTTTACAATACATGC AATGGAAGACTTTAATTTCCTCTTCTTATAATTTTGCTTCCATTCAATTACCAATTTTAA GCTGACATTTGAAAACACCCAGCCAAATATATCCTTCTTCAGTTTAATTAACATGGCCTA TTGTCTTACAGGAAAAAATACAAAATTAAGATTAATTCTTATAAGGAACTCAGCTCAACA TCAGGTTTATATGACAAGAGATAGTATCAGCAAATATAACTATACAATTGAGAACCATCT ATGGCACTATGATTCTTATATTATGTTTTCTGAATTACAATCTTAAAACAAGGATCATAC CCTATTCTACTCTTTTAAGCCTTGTTTTAAGCATTTGCTCCACTCTTTACAACAGAACAT TGTATACCTCCATCCCACATCCAAAAAAAAGATGTGCTGTAAGAAAAGTTACATTTTCAT TTAAAAAATTACACATATAAATCANAACCTATGTTAAATATTTAATACTCTCTCCACCCA ACGTGAACAGTTTTGTATGAAAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005544 |
| Insert Size | 5000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005544.1, NP_005535.1 |
| RefSeq Size | 5828 bp |
| RefSeq ORF | 3729 bp |
| Locus ID | 3667 |
| UniProt ID | P35568 |
| Protein Families | Druggable Genome |
| Protein Pathways | Adipocytokine signaling pathway, Insulin signaling pathway, Neurotrophin signaling pathway, Type II diabetes mellitus |
| Gene Summary | This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma
,Tomasetti, M;Monaco, F;Manzella, N;Rohlena, J;Rohlenova, K;Staffolani, S;Gaetani, S;Ciarapica, V;Amati, M;Bracci, M;Valentino, M;Goodwin, J;Nguyen, M;Truksa, J;Sobol, M;Hozak, P;Dong, LF;Santarelli, L;Neuzil, J;,
Oncotarget
,PubMed ID 27119351
[IRS1]
|
|
The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
,null,
Science signaling
,PubMed ID 25690013
[IRS1]
|
|
Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats
,Li, Y;Wang, J;Gu, T;Yamahara, J;Li, Y;,
Toxicol. Appl. Pharmacol. 155-163 277 2. April 2014
,PubMed ID 24704288
[IRS1]
|
|
Gene expression of the IGF pathway family distinguishes subsets of gastrointestinal stromal tumors wild type for KIT and PDGFRA
,null,
Cancer Medicine
,PubMed ID 24133624
[IRS1]
|
Documents
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Resources
Other Versions
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|---|---|---|---|
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| RC208765L1 | Lenti-ORF clone of IRS1 (Myc-DDK-tagged)-Human insulin receptor substrate 1 (IRS1) |
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| RC208765L2 | Lenti-ORF clone of IRS1 (mGFP-tagged)-Human insulin receptor substrate 1 (IRS1) |
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| RC208765L3 | Lenti-ORF clone of IRS1 (Myc-DDK-tagged)-Human insulin receptor substrate 1 (IRS1) |
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| RC208765L4 | Lenti-ORF clone of IRS1 (mGFP-tagged)-Human insulin receptor substrate 1 (IRS1) |
CNY 11,048.00 |
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| RG208765 | IRS1 (tGFP-tagged) - Human insulin receptor substrate 1 (IRS1) |
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