United States
Germany
Japan
United Kingdom
China
IL12B (NM_002187) Human Untagged Clone
CAT＃: SC124116
IL12B (untagged)-Human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B)
CNY 2,400.00
CNY 2,950.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC124116 sequence for NM_002187 edited (data generated by NextGen Sequencing)
ATGTGTCACCAGCAGTTGGTCATCTCTTGGTTTTCCCTGGTTTTTCTGGCATCTCCCCTC GTGGCCATATGGGAACTGAAGAAAGATGTTTATGTCGTAGAATTGGATTGGTATCCGGAT GCCCCTGGAGAAATGGTGGTCCTCACCTGTGACACCCCTGAAGAAGATGGTATCACCTGG ACCTTGGACCAGAGCAGTGAGGTCTTAGGCTCTGGCAAAACCCTGACCATCCAAGTCAAA GAGTTTGGAGATGCTGGCCAGTACACCTGTCACAAAGGAGGCGAGGTTCTAAGCCATTCG CTCCTGCTGCTTCACAAAAAGGAAGATGGAATTTGGTCCACTGATATTTTAAAGGACCAG AAAGAACCCAAAAATAAGACCTTTCTAAGATGCGAGGCCAAGAATTATTCTGGACGTTTC ACCTGCTGGTGGCTGACGACAATCAGTACTGATTTGACATTCAGTGTCAAAAGCAGCAGA GGCTCTTCTGACCCCCAAGGGGTGACGTGCGGAGCTGCTACACTCTCTGCAGAGAGAGTC AGAGGGGACAACAAGGAGTATGAGTACTCAGTGGAGTGCCAGGAGGACAGTGCCTGCCCA GCTGCTGAGGAGAGTCTGCCCATTGAGGTCATGGTGGATGCCGTTCACAAGCTCAAGTAT GAAAACTACACCAGCAGCTTCTTCATCAGGGACATCATCAAACCTGACCCACCCAAGAAC TTGCAGCTGAAGCCATTAAAGAATTCTCGGCAGGTGGAGGTCAGCTGGGAGTACCCTGAC ACCTGGAGTACTCCACATTCCTACTTCTCCCTGACATTCTGCGTTCAGGTCCAGGGCAAG AGCAAGAGAGAAAAGAAAGATAGAGTCTTCACGGACAAGACCTCAGCCACGGTCATCTGC CGCAAAAATGCCAGCATTAGCGTGCGGGCCCAGGACCGCTACTATAGCTCATCTTGGAGC GAATGGGCATCTGTGCCCTGCAGTTAG Clone variation with respect to NM_002187.2 >OriGene 5' read for NM_002187 unedited
CGCGGAAAGTCAGGATTTGTATCACGATCTCATATAGGCGGCCGCCAGTGTGATGGATAT CTGCAGAATTCGGCTTCAGAGCAAGATGTGTCACCAGCAGTTGGTCATCTCTTGGTTTTC CCTGGTTTTTCTGGCATCTCCCCTCGTGGCCATATGGGAACTGAAGAAAGATGTTTATGT CGTAGAATTGGATTGGTATCCGGATGCCCCTGGAGAAATGGTGGTCCTCACCTGTGACAC CCCTGAAGAAGATGGTATCACCTGGACCTTGGACCAGAGCAGTGAGGTCTTAGGCTCTGG CAAAACCCTGACCATCCAAGTCAAAGAGTTTGGAGATGCTGGCCAGTACACCTGTCACAA AGGAGGCGAGGTTCTAAGCCATTCGCTCCTGCTGCTTCACAAAAAGGAAGATGGAATTTG GTCCACTGATATTTTAAAGGACCAGAAAGAACCCAAAAATAAGACCTTTCTAAGATGCGA GGCCAAGAATTATTCTGGACGTTTCACCTGCTGGTGGCTGACGACAATCAGTACTGATTT GACATTCAGTGTCAAAAGCAGCAGAGGCTCTTCTGACCCCCAAGGGGTGACGTGCGGAGC TGCTACACTCTCTGCAGAGAGAGTCAGAGGGGACAACAAGGAGTATGAGTACTCAGTGGA GTGCCAGGAGGACAGTGCCTGCCCAGCTGCTGAGGAGAGTCTGCCCATTGAGGTCATGGT TGGATGCCGTTCACAAGCTCAAGTATGAAAACTACACCCGCAGCTTCTTCATCAGGGACA TCATCAAACCTGACCCACCCAAGAACTTGCAGCTGGAAGCCATTAAGGATTTCTCGCCGG TGGGAGGTCACCTTGGAAGTACCCTGACACCTG >OriGene 3' read for NM_002187 unedited
TGGGGNAGGGNNNNATGCACTGCATTCAACTTCCAGGCCGNANAACACTGGGGAGGGGTC ACAGGGATGCCACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAG TCGACAAGCTTGATATCGGTACCGAGCTCGGATCCACTAGTAACGGCCGCCAGTGTGCTG GAATTCGGCTTTTTCATCCTGGATCAGAACCTAACTGCAGGGCACAGATGCCCATTCGCT CCAAGATGAGCTATAGTAGCGGTCCTGGGCCCGCACGCTAATGCTGGCATTTTTGCGGCA GATGACCGTGGCTGAGGTCTTGTCCGTGAAGACTCTATCTTTCTTTTCTCTCTTGCTCTT GCCCTGGACCTGAACGCAGAATGTCAGGGAGAAGTAGGAATGTGGAGTACTCCAGGTGTC AGGGTACTCCCAGCTGACCTCCACCTGCCGAGAATTCTTTAATGGCTTCAGCTGCAAGTT CTTGGGTGGGTCAGGTTTGATGATGTCCCTGATGAAGAAGCTGCTGGTGTAGTTTTCATA CTTGAGCTTGTGAACGGCATCCACCATGACCTCAATGGGCAGACTCTCCTCAGCAGCTGG GCAGGCACTGTCCTCCTGGCACTCCACTGAGTACTCATACTCCTTGTTGTCCCCTCTGAC TCTCTCTGCAGAGAGTGTAGCAGCTCCGCACGTCACCCCTTTGGGGTCAGAAGAGCCTCT GCTGCTTTGACACTGAATGTCAAATCAGTACTGATTTGCGTCAGCCACCAGCAGGTGAAA CGTCCAGAATAATTCTTGGCTN |
| Restriction Sites | Please inquire |
| ACCN | NM_002187 |
| Insert Size | 1100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002187.2, NP_002178.2 |
| RefSeq Size | 2347 bp |
| RefSeq ORF | 987 bp |
| Locus ID | 3593 |
| UniProt ID | P29460 |
| Domains | FN3 |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus |
| Gene Summary | This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209679 | IL12B (Myc-DDK-tagged)-Human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B) |
CNY 2,400.00 |
|
| RC209679L1 | Lenti ORF clone of Human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC209679L2 | Lenti ORF clone of Human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), mGFP tagged |
CNY 5,890.00 |
|
| RC209679L3 | Lenti ORF clone of Human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC209679L4 | Lenti ORF clone of Human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), mGFP tagged |
CNY 4,800.00 |
|
| RG209679 | IL12B (tGFP-tagged) - Human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B) |
CNY 4,000.00 |
