United States
Germany
Japan
United Kingdom
China
Repulsive Guidance Molecule C (HFE2) (NM_145277) Human Untagged Clone
CAT＃: SC124916
HFE2 (untagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant b
CNY 2,400.00
CNY 2,950.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HFE2; HFE2A; JH; RGMC |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC124916 sequence for NM_145277 edited (data generated by NextGen Sequencing)
ATGATCCAGCACAACTGCTCCCGCCAGGGCCCTACAGCCCCTCCCCCGCCCCGGGGCCCC GCCCTTCCAGGCGCGGGCTCCGGCCTCCCTGCCCCGGACCCTTGTGACTATGAAGGCCGG TTTTCCCGGCTGCATGGTCGTCCCCCGGGGTTCTTGCATTGCGCTTCCTTCGGGGACCCC CATGTGCGCAGCTTCCACCATCACTTTCACACATGCCGTGTCCAAGGAGCTTGGCCTCTA CTGGATAATGACTTCCTCTTTGTCCAAGCCACCAGCTCCCCCATGGCGTTGGGGGCCAAC GCTACCGCCACCCGGAAGCTCACCATCATATTTAAGAACATGCAGGAATGCATTGATCAG AAGGTGTATCAGGCTGAGGTGGATAATCTTCCTGTAGCCTTTGAAGATGGTTCTATCAAT GGAGGTGACCGACCTGGGGGATCCAGTTTGTCGATTCAAACTGCTAACCCTGGGAACCAT GTGGAGATCCAAGCTGCCTACATTGGCACAACTATAATCATTCGGCAGACAGCTGGGCAG CTCTCCTTCTCCATCAAGGTAGCAGAGGATGTGGCCATGGCCTTCTCAGCTGAACAGGAC CTGCAGCTCTGTGTTGGGGGGTGCCCTCCAAGTCAGCGACTCTCTCGATCAGAGCGCAAT CGTCGGGGAGCTATAACCATTGATACTGCCAGACGGCTGTGCAAGGAAGGGCTTCCAGTG GAAGATGCTTACTTCCATTCCTGTGTCTTTGATGTTTTAATTTCTGGTGATCCCAACTTT ACCGTGGCAGCTCAGGCAGCACTGGAGGATGCCCGAGCCTTCCTGCCAGACTTAGAGAAG CTGCATCTCTTCCCCTCAGATGCTGGGGTTCCTCTTTCCTCAGCAACCCTCTTAGCTCCA CTCCTTTCTGGGCTCTTTGTTCTGTGGCTTTGCATTCAGTAA Clone variation with respect to NM_145277.4 >OriGene 5' read for NM_145277 unedited
CCGGCGTCCAGAATTTGTATACGATCTCACTATAGGCGGCCGCGAATTCGCACCAGACAC GGAGGACCCCTGGCTGGACTGACCCACAGATAGGGAANATGGCTGGAGAATTGGATAGCA GAGTAATGTTTGACCTCTGGAAACACTCATTCTCAATGCAAGATCCTCCGCTGCAATGCT GAGTACGTATCGTCCACTCTGAGCCTTAGAGGTGGGGGTTCATCAGGAGCACTTCGAGGA GGAGGAGGAGGAGGCCGGGGTGGAGGGGTGGGCTCTGGCGGCCTCTGTCGAGCCCTCCGC TCCTATGCGCTCTGCACTCGGCGCACCGCCCGCACCTGCCGCGGGGACCTCGCCTTCCAT TCGGCGGTACATGGCATCGAAGACCTGATGATCCAGCACAACTGCTCCCGCCAGGGCCCT ACAGCCCCTCCCCCGCCCCGGGGCCCCGCCCTTCCAGGCGCGGGCTCCGGCCTCCCTGCC CCGGACCCTTGTGACTATGAAGGCCGGTTTTCCCGGCTGCATGGTCGTCCCCCGGGGTTC TTGCATTGCGCTTCCTTCGGGGACCCCCATGTGCGCAGCTTCCACCATCACTTTCACACA TGCCGTGTCCAAGGAGCTTGGCCTCTACTGGATAATGACTTCCTCTTTGTCCAAGCCACC AGCTCCCCCATGGCGTTGGGGGCCAACGCTACCGCCACCCGGAAGCTCACCATCATATTT AAGAACATGCAGGAATGCATTGATCAGAAAGTGTATCAGGCCTGAGTGGATAATCTTCCT GTAGCCTTTGAAATGGTTCTATCAATGGAGGTGACCGACCTGGGGGNATCCAGTTTGTCG ATTCAAACTGCTAAACCCTGGAACCATGTTGAGATCCAGCC >OriGene 3' read for NM_145277 unedited
ACGACATCGAGNNACCGCGGCCGCATTCTANATCGAGTTTTTTTTTTTTTTTTTTGGTGT GAAGAATTTGTAGCTTTAATAACAGATTAGTTAGGGGGTAGGGATGATACTTCTGTCCTA CCTGTGCCATTCTTCAAAAGCAGAGACTCCCTTCACCTAAGAGCTAGACAATGCCTGCTT CATTTTTGAATCAAGAAAGCAGAACATACCTTACACACTCATATTCATCAAATAGACTTC TTTCCCTAATTATGTCTTCCTCCTTTGAGTTTCTTATGGCTAATGATCATGTCTTCTGCT TTCAGCTCTTGCCTCTTAAAAATCTCAACCCTTAAATCTTTACTGATCATTAAAACCTTC ATGACCTCTAAACTTATAAGGGTGAAATCTGCAGTAAATGGATTATAACAATTTGTTTAC TATAAATGAGGCTGGAAAAATTGGTGAAGAGCCCCACAGAGATCCGGAATGCAGTAACCT TGCCCAGAATCCTTATTCTGAGATAATTTCAACCCTGGACTGCAGCCTCATCTGACCCTG GAAATGTCATTGTTTCACGTGTCTCCTATGCCCTGCATCCTAAAAGAAATCTTTAAATCC CTCTATGCCAATCTGTGTCTACAAAACATTCTTCAAACATGAATGGGGACTGAAGGCCCC CTTAACAGAAGGGCAAGACCAGAAACAAAGAAGCCCAAAAAACTAGGGCAGCCTATATAC GGTTTACTGTGTAGAAAATTAATCAATATGTTATAAAATGAAATAACAATATCCTCCCTC TTATTGTTGGTAGGAAAGGCTCCGAGCCATATAATAAATTATTGTACTTAGTCTTGCACG GTGATAGAATAATGTGACGACCCGACAATATAAATACATCTAAAATGTCACCCAAGCGAG ACATGTTAACTTACGACACTAATAGAAAGAACCTATCGTTACGAN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_145277 |
| Insert Size | 2050 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_145277.3, NP_660320.3 |
| RefSeq Size | 1961 bp |
| RefSeq ORF | 942 bp |
| Locus ID | 148738 |
| UniProt ID | Q6ZVN8 |
| Protein Families | Transmembrane |
| Gene Summary | The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015] Transcript Variant: This variant (b) lacks a segment in the 5' UTR and an in-frame portion of the 5' coding region, compared to variant a. The resulting isoform (b) has a shorter N-terminus when compared to isoform a. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC220228 | HFE2 (Myc-DDK-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant b |
CNY 2,400.00 |
|
| RC220228L3 | Lenti ORF clone of Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant b, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC220228L4 | Lenti ORF clone of Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant b, mGFP tagged |
CNY 5,890.00 |
|
| RG220228 | HFE2 (tGFP-tagged) - Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant b |
CNY 4,000.00 |
其它Repulsive Guidance Molecule C产品
