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IDO1 (NM_002164) Human Untagged Clone
CAT＃: SC126221
IDO1 (untagged)-Human indoleamine 2,3-dioxygenase 1 (IDO1)
CNY 5,488.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IDO; IDO-1; INDO |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002164 edited
AAACTCTTCAGACACTGAGGGGCACCAGAGGAGCAGACTACAAGAATGGCACACGCTATG GAAAACTCCTGGACAATCAGTAAAGAGTACCATATTGATGAAGAAGTGGGCTTTGCTCTG CCAAATCCACAGGAAAATCTACCTGATTTTTATAATGACTGGATGTTCATTGCTAAACAT CTGCCTGATCTCATAGAGTCTGGCCAGCTTCGAGAAAGAGTTGAGAAGTTAAACATGCTC AGCATTGATCATCTCACAGACCACAAGTCACAGCGCCTTGCACGTCTAGTTCTGGGATGC ATCACCATGGCATATGTGTGGGGCAAAGGTCATGGAGATGTCCGTAAGGTCTTGCCAAGA AATATTGCTGTTCCTTACTGCCAACTCTCCAAGAAACTGGAACTGCCTCCTATTTTGGTT TATGCAGACTGTGTCTTGGCAAACTGGAAGAAAAAGGATCCTAATAAGCCCCTGACTTAT GAGAACATGGACGTTTTGTTCTCATTTCGTGATGGAGACTGCAGTAAAGGATTCTTCCTG GTCTCTCTATTGGTGGAAATAGCAGCTGCTTCTGCAATCAAAGTAATTCCTACTGTATTC AAGGCAATGCAAATGCAAGAACGGGACACTTTGCTAAAGGCGCTGTTGGAAATAGCTTCT TGCTTGGAGAAAGCCCTTCAAGTGTTTCACCAAATCCACGATCATGTGAACCCAAAAGCA TTTTTCAGTGTTCTTCGCATATATTTGTCTGGCTGGAAAGGCAACCCCCAGCTATCAGAC GGTCTGGTGTATGAAGGGTTCTGGGAAGACCCAAAGGAGTTTGCAGGGGGCAGTGCAGGC CAAAGCAGCGTCTTTCAGTGCTTTGACGTCCTGCTGGGCATCCAGCAGACTGCTGGTGGA GGACATGCTGCTCAGTTCCTCCAGGACATGAGAAGATATATGCCACCAGCTCACAGGAAC TTCCTGTGCTCATTAGAGTCAAATCCCTCAGTCCGTGAGTTTGTCCTTTCAAAAGGTGAT GCTGGCCTGCGGGAAGCTTATGACGCCTGTGTGAAAGCTCTGGTCTCCCTGAGGAGCTAC CATCTGCAAATCGTGACTAAGTACATCCTGATTCCTGCAAGCCAGCAGCCAAAGGAGAAT AAGACCTCTGAAGACCCTTCAAAACTGGAAGCCAAAGGAACTGGAGGCACTGATTTAATG AATTTCCTGAAGACTGTAAGAAGTACAACTGAGAAATCCCTTTTGAAGGAAGGTTAATGT AACCCAACAAGAGCACATTTTATCATAGCAGAGACATCTGTATGCATTCCTGTCATTACC CATTGTAACAGAGCCACAAACTAATACTATGCAATGTTTTACCAATAATGCAATACAAAA GACCTCAAAATACCTGTGCATTTCTTGTAGGAAAACAACAAAAGGTAATTATGTGTAATT ATACTAGAAGTTTTGTAATCTGTATCTTATCATTGGAATAAAATGACATTCAATAAATAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_002164 unedited
ATGATTTGTATACCACTCTTATAGGCGGACCGCGATTCAGATCTGGTACCGGTCCGGAAT TCCCGGGATAAAACTCTTCAGACACTGAGGGGCACCAGAGGAGCAGACTACAAGAATGGC ACACGCTATGGAAAACTCCTGGACAATCAGTAAAGAGTACCATATTGATGAAGAAGTGGG CTTTGCTCTGCCAAATCCACAGGAAAATCTACCTGATTTTTATAATGACTGGATGTTCAT TGCTAAACATCTGCCTGATCTCATAGAGTCTGGCCAGCTTCGAGAAAGAGTTGAGAAGTT AAACATGCTCAGCATTGATCATCTCACAGACCACAAGTCACAGCGCCTTGCACGTCTAGT TCTGGGATGCATCACCATGGCATATGTGTGGGGCAAAGGTCATGGAGATGTCCGTAAGGT CTTGCCAAGAAATATTGCTGTTCCTTACTGCCAACTCTCCAAGAAACTGGAACTGCCTCC TATTTTGGTTTATGCAGACTGTGTCTTGGCAAACTGGAAGAAAAAGGATCCTAATAAGCC CCTGACTTATGAGAACATGGACGTTTTGTTCTCATTTCGTGATGGAGACTGCAGTAAAGG ATTCTTCCTGGTCTCTCTATTGGTGGAATAGCAGCTGCTTCTGCAATCAAAGTAATTCCT ACTGTATTCAAGCAATGCAAATGCAAGAACGGGACACTTTGCTAAAGGCGCTGNTGGAAA TAGCCTCTTGCTTGGAGAAAGCCCTTCAGTGTTTCACCAATCCACGATCATGTGACCCAA AGCTTTTTTCAGGGTCCTCGCTATATTTGGCTGGCTGGAAGGGAACCCCACTTTCAAACG TCTGGTGTATAAAGGGTTTTGGAAACCCAAGGAATTGCAGGGGAATGAAGGCCAACAACG TCTTCAAGGTTTGACGCCCGGTGGGCATCCCAGACGGT |
| Restriction Sites | Please inquire |
| ACCN | NM_002164 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002164.3, NP_002155.1 |
| RefSeq Size | 1655 bp |
| RefSeq ORF | 1212 bp |
| Locus ID | 3620 |
| UniProt ID | P14902 |
| Protein Families | Druggable Genome |
| Protein Pathways | Metabolic pathways, Tryptophan metabolism |
| Gene Summary | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Systemic Delivery of Salmonella typhimurium Transformed with IDO shRNA Enhances Intratumoral Vector Colonization and Suppresses Tumor Growth
,Céline A. Blache, Edwin R. Manuel, Teodora I. Kaltcheva, Andrea N. Wong, Joshua D.I. Ellenhorn, Bruce R. Blazar, and Don J. Diamond,
Cancer Res., Dec 2012; 72: 6447 - 6456.
[IDO1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC206592 | IDO1 (Myc-DDK-tagged)-Human indoleamine 2,3-dioxygenase 1 (IDO1) |
CNY 5,488.00 |
|
| RC206592L1 | Lenti ORF clone of Human indoleamine 2,3-dioxygenase 1 (IDO1), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC206592L2 | Lenti ORF clone of Human indoleamine 2,3-dioxygenase 1 (IDO1), mGFP tagged |
CNY 7,888.00 |
|
| RC206592L3 | Lenti ORF clone of Human indoleamine 2,3-dioxygenase 1 (IDO1), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC206592L4 | Lenti ORF clone of Human indoleamine 2,3-dioxygenase 1 (IDO1), mGFP tagged |
CNY 7,888.00 |
|
| RG206592 | IDO1 (tGFP-tagged) - Human indoleamine 2,3-dioxygenase 1 (IDO1) |
CNY 7,088.00 |
