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SMC1 (SMC1A) (NM_006306) Human Untagged Clone
CAT＃: SC126775
SMC1A (untagged)-Human structural maintenance of chromosomes 1A (SMC1A)
CNY 8,592.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1; SMC1alpha; SMC1L1; SMCB |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC126775 sequence for NM_006306 edited (data generated by NextGen Sequencing)
ATGGGGTTCCTGAAACTGATTGAGATTGAGAACTTTAAGTCGTACAAGGGTCGACAGATT ATCGGACCATTTCAGAGGNNNNNNGCCATCATTGGACCCAATGGCTCTGGTAAGTCAAAT CTCATGGATGCCATCAGCTTTGTGCTAGGTGAAAAAACCAGCAACCTGCGGGTAAAGACC CTGCGGGACCTGATCCATGGAGCTCCTGTGGGCAAGCCAGCTGCCAACCGGGCCTTTGTC AGCATGGTCTACTCTGAGGAGGGTGCTGAGGACCGTACCTTTGCCCGTGTCATTGTAGGA GGTTCTTCTGAGTACAAGATCAACAACAAAGTGGTCCAACTACATGAGTACAGTGAGGAA TTAGAGAAGTTGGGCATTCTCATCAAAGCTCGTAACTTCCTCGTTTTCCAGGGTGCTGTG GAATCTATTGCCATGAAGAACCCCAAAGAGAGGACAGCTCTATTTGAAGAGATTAGTCGT TCTGGGGAGCTGGCGCAGGAGTATGACAAGCGAAAGAAGGAAATGGTGAAGGCTGAAGAG GACACACAGTTTAATTACCATCGCAAGAAAAATATTGCGGCTGAACGCAAGGAAGCAAAG CAGGAGAAAGAAGAGGCTGACCGGTACCAGCGCCTGAAGGATGAGGTAGTACGGGCTCAG GTACAGCTGCAGCTCTTTAAGCTTTACCATAATGAAGTGGAAATTGAGAAGCTCAACAAG GAACTGGCCTCAAAGAACAAGGAGATCGAGAAGGACAAGAAGCGTATGGACAAGGTGGAG GATGAACTGAAGGAGAAGAAGAAGGAGCTGGGCAAAATGATGCGGGAGCAGCAGCAGATT GAGAAGGAGATCAAGGAGAAGGACTCAGAATTGAACCAGAAGCGGCCTCAGTACATCAAA GCCAAGGAGAACACCTCCCACAAAATCAAGAAGCTGGAAGCAGCCAAGAAGTCTCTGCAG AATGCTCAGAAGCACTACAAGAAGCGTAAAGGTGACATGGATGAGCTGGAGAAGGAGATG CTGTCAGTGGAGAAGGCTCGGCAGGAGTTTGAAGAACGGATGGAAGAAGAGAGTCAGAGT CAGGGCAGAGATTTGACGTTGGAGGAGAATCAGGTGAAGAAATACCACCGGTTGAAAGAA GAAGCCAGCAAGAGAGCAGCTACCCTGGCCCAGGAGCTGGAGAAATTCAATCGAGACCAG AAAGCTGACCAGGACCGTCTGGATCTGGAAGAACGGAAGAAAGTAGAGACAGAGGCCAAG ATCAAGCAAAAGCTGCGGGAAATTGAAGAGAATCAGAAGCGGATTGAGAAACTGGAGGAA TACATCACCACTAGCAAGCAGTCCCTAGAAGAGCAGAAGAAGCTAGAGGGGGAGCTGACA GAGGAGGTGGAGATGGCCAAGCGGCGTATTGATGAAATCAATAAGGAGCTGAACCAGGTG ATGGAGCAGCTAGGGGATGCCCGCATCGACCGCCAGGAGAGCAGCCGCCAGCAGCGAAAG GCAGAGATAATGGAAAGCATCAAGCGCCTTTACCCTGGCTCTGTGTACGGCCGCCTCATT GACCTATGCCAGCCCACACAAAAGAAGTATCAGATTGCTGTAACCAAGGTTTTGGGCAAG AACATGGATGCCATTATTGTGGACTCGGAGAAGACAGGCCGGGACTGTATTCAGTATATC AAGGAGCAGCGTGGGGAGCCTGAGACCTTCTTGCCTCTTGACTACCTGGAGGTGAAGCCT ACAGATGAGAAACTCCGGGAGCTGAAGGGGGCCAAGCTAGTGATTGATGTGATTCGCTAT GAGCCACCTCATATCAAAAAGGCCCTGCAGTATGCTTGTGGCAATGCCCTTGTCTGTGAC AACGTGGAAGATGCCCGCCGCATTGCCTTTGGAGGCCACCAGCGCCACAAGACAGTGGCA CTGGATGGAACCCTATTCCAGAAGTCAGGAGTGATCTCTGGTGGGGCCAGTGACCTGAAG GCCAAGGCACGGCGCTGGGATGAGAAAGCAGTAGACAAGTTGAAAGAGAAGAAGGAGCGC TTGACAGAGGAGCTGAAAGAGCAGATGAAGGCAAAACGGAAAGAGGCAGAGCTGCGTCAG GTGCAGTCTCAGGCCCATGGACTGCAGATGCGGCTCAAGTACTCCCAGAGTGACCTAGAA CAGACCAAGACACGACATCTAGCCCTGAATCTGCAGGAAAAATCCAAGCTGGAGAGTGAG CTAGCCAACTTTGGGCCTCGCATTAATGATATCAAGAGGATCATTCAGAGCCGAGAGAGG GAAATGAAAGACTTGAAGGAGAAGATGAACCAGGTAGAGGATGAGGTGTTTGAAGAGTTT TGTCGGGAGATTGGTGTGCGCAACATCCGGGAGTTTGAGGAAGAAAAGGTGAAACGGCAG AATGAAATCGCCAAGAAGCGTTTGGAGTTTGAGAATCAGAAGACTCGCTTGGGCATTCAG TTGGATTTTGAAAAGAACCAACTGAAGGAGGACCAAGATAAAGTACACATGTGGGAGCAG ACAGTGAAAAAAGATGAAAATGAGATAGAAAAGCTCAAAAAGGAGGAACAAAGACACATG AAGATCATAGATGAGACCATGGCTCAGCTACAAGACCTGAAGAATCAGCATCTGGCCAAG AAGTCGGAAGTGAATGACAAGAATCATGAGATGGAGGAGATTCGTAAGAAACTCGGGGGC GCCAACAAGGAAATGACCCATTTACAGAAGGAGGTGACAGCCATTGAGACCAAGCTTGAA CAGAAGCGCAGTGACCGTCACAACTTGCTACAGGCCTGTAAGATGCAGGACATTAAGTTG CCACTGTCAAAAGGCACCATGGATGATATTAGTCAGGAAGAGGGTAGCTCCCAGGGGGAG GACTCAGTGAGTGGTTCACAGAGAATTTCCAGTATCTATGCACGAGAGGCCCTCATTGAG ATTGACTACGGTGATCTGTGTGAGGATCTGAAGGATGCCCAGGCTGAGGAAGAGATCAAG CAAGAGATGAACACACTGCAGCAGAAGCTGAATGAGCAGCAGAGTGTGCTTCAGCGTATT GCCGCCCCCAACATGAAGGCCATGGAAAAGCTGGAAAGTGTCCGAGACAAGTTCCAGGAG ACCTCAGATGAGTTTGAAGCAGCCCGAAAGCGAGCAAAGAAGGCCAAGCAGGCATTCGAA CAGATCAAGAAGGAGCGCTTTGACCGCTTCAATGCTTGTTTTGAATCTGTGGCTACCAAC ATTGATGAGATCTATAAGGCCCTGTCCCGCAATAGCAGTGCCCAGGCATTCCTGGGCCCT GAGAACCCTGAAGAGCCCTACTTGGATGGCATCAACTACAACTGTGTGGCTCCTGGGAAA CGCTTCCGGCCTATGGACAACTTGTCAGGCGGGGAGAAGACAGTGGCAGCTCTGGCCCTG CTCTTTGCCATCCACAGCTACAAGCCAGCCCCCTTCTTCGTCCTGGATGAGATTGATGCT GCCTTGGATAACACCAACATTGGCAAGGTGGCAAATTACATCAAGGAGCAGTCGACTTGC AACTTCCAGGCCATCGTCATCTCTCTCAAGGAGGAGTTCTACACCAAGGCCGAGAGCCTC ATTGGAGTCTATCCTGAGCAAGGGGACTGTGTGATCAGCAAAGTCCTGACCTTCGACCTC ACCAAGTACCCAGATGCCAACCCCAACCCCAATGAGCAGTAG Clone variation with respect to NM_006306.2 79 t=>n;80 t=>n;81 c=>n;82 a=>n;83 c=>n;84 c=>n >OriGene 5' read for NM_006306 unedited
TTCCCGCGCGGGCTACCTCAGTTCTCGGGCGTACGGCGCGGCCTGTCCTACTGCCGCCGG CGCCGCGGCCGTCATGGGGTTCCTGAAACTGATTGAGATTGAGAACTTTAAGTCGTACAA GGGTCGACAGATTATCGGACCATTTCAGAGGTTCACCGCCATCATTGGACCCAATGGCTC TGGTAAGTCAAATCTCATGGATGCCATCAGCTTTGTGCTAGGTGAAAAAACCAGCAACCT GCGGGTAAAGACCCTGCGGGACCTGATCCATGGAGCTCCTGTGGGCAAGCCAGCTGCCAA CCGGGCCTTTGTCAGCATGGTCTACTCTGAGGAGGGTGCTGAGGACCGTACCTTTGCCCG TGTCATTGTAGGAGGTTCTTCTGAGTACAAGATCAACAACAAAGTGGTCCAACTACATGA GTACAGTGAGGAATTAGAGAAGTTGGGCATTCTCATCAAAGCTCGTAACTTCCTCGTTTT CCAGGGTGCTGTGGAATCTATTGCCATGAAGAACCCCAAAGAGAGGACAGCTCTATTTGA AGAGATTAGTCGTTCTGGGGAGCTGGCGCAGGAGTATGACAAGCGAAAGAAGGAAATGGT GAAGGCTGAAGAGGACACACAGTTTAATTACCATCGCAAGAAAAATATTGCGGCTGAACG CAAGGAAGC >OriGene 3' read for NM_006306 unedited
NGGGCGTACTGTGNACCGCGGCCGCAATTCTANATCGAGTTTTTTTTTTTTTTTTTTTTT TTNTCTAAAACAGGGTCTCCAATATCCTTTATTATTTTGCAAACATACTCACATGCACAC ATGCGGATACATACATACACACATACATACCCACACACACAGTGGGCAAAAGGCCCAAGG GGCCCACGATTATGGGTGATGAGGGGGAGGAAGGGGGCCTTTCTTTTTTTTTTGTTAAAT CACCACCCCTTTCTATTATCTTATACTATCTGCCCCCCTTGGACACCTCTTTTGCCCCTC ACTAAACCTTTCCTCTCCCACCATATCTCTCCCCTACACTTTACATGTCTTCACTTCTCG CTGATTCTTTATTCATACCATCATACTCACCTTAGTATCTCCATAATAATCTCATTAGCG CTGCCGTCCACTTAGTCTCTGCCGCACAGCTGACTCCATCTTCTTTCTGCCTTGTCTCAT ATAGACTAACCTTAACCAGCTCAGGATTCGAACCTCGCAGACCAGCCAATATATTAGAGT ACGAGGAGAGGAGCGAAGTCCTAGTTAGAAGACCATATGTACGCGAGTTGGCCAGATTAG CTACAGACCTTAAGATTCCGCAGAAATTAGTATGCCGCCAGTAGATAGCATAGGAACAAT TCACCTTAGTCCTCACATATCGATCAATATATTCACCCGCTTTAACGCGATATCTCAGTA AGTGCCGACACCCGATTATGTGAATCATGAGAGATCGGATGCGAGTAATTCAACGATTTA TTGGAATTCAAGACATGATACACACAGACACATTANCATGATATAGACCTACAAGTATGC AAGCACAACAATGGCCGCACATATATAGCAGAGATAACTATAAGGATATCAGACGAGGGA CAATGCTCACTGTAGACGACGTAAGTAATTAAAGAGACAATGTAATAGTAACATTAGAGT GACACATTCAAAATAGCACACGCGGAGCACACACAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006306 |
| Insert Size | 4350 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_006306.2, NP_006297.2 |
| RefSeq Size | 9725 bp |
| RefSeq ORF | 3702 bp |
| Locus ID | 8243 |
| UniProt ID | Q14683 |
| Domains | SMC_N, SMC_C, KID |
| Protein Families | Druggable Genome |
| Protein Pathways | Cell cycle, Oocyte meiosis |
| Gene Summary | Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Mutant cohesin drives chromosomal instability in early colorectal adenomas
,Cucco, F;Servadio, A;Gatti, V;Bianchi, P;Mannini, L;Prodosmo, A;De Vitis, E;Basso, G;Friuli, A;Laghi, L;Soddu, S;Fontanini, G;Musio, A;,
Hum. Mol. Genet. July 2014
,PubMed ID 25080505
[SMC1A]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215888 | SMC1A (Myc-DDK-tagged)-Human structural maintenance of chromosomes 1A (SMC1A) |
CNY 8,584.00 |
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| RC215888L3 | Lenti ORF clone of Human structural maintenance of chromosomes 1A (SMC1A), Myc-DDK-tagged |
CNY 7,600.00 |
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| RC215888L4 | Lenti ORF clone of Human structural maintenance of chromosomes 1A (SMC1A), mGFP tagged |
CNY 7,600.00 |
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| RG215888 | SMC1A (tGFP-tagged) - Human structural maintenance of chromosomes 1A (SMC1A) |
CNY 10,184.00 |
