United States
Germany
Japan
United Kingdom
China
NUP98 (NM_005387) Human Untagged Clone
CAT＃: SC127839
NUP98 (untagged)-Human nucleoporin 98kDa (NUP98), transcript variant 3
CNY 6,872.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ADIR2; NUP96; Nup98-96; NUP196 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_005387, the custom clone sequence may differ by one or more nucleotides
ATGTTTAACAAATCATTTGGAACACCCTTTGGGGGTGGCACAGGTGGCTTTGGCACAACTTCAACATTTG GACAGAATACTGGCTTTGGCACTACTAGTGGAGGGGCATTTGGAACATCTGCATTTGGTTCTAGCAACAA TACTGGAGGCCTCTTTGGAAATTCACAGACTAAACCAGGAGGATTGTTTGGAACCAGTTCATTTAGCCAG CCAGCTACCTCCACAAGCACTGGCTTTGGGTTTGGTACGTCAACAGGAACAGCAAATACCTTGTTTGGAA CTGCAAGCACAGGGACCAGTCTCTTCTCATCCCAAAACAATGCCTTTGCACAAAATAAACCAACTGGCTT TGGCAATTTTGGAACCAGTACTAGCAGTGGAGGACTCTTTGGAACCACAAATACCACCTCTAATCCTTTT GGCAGCACATCTGGCTCCCTCTTTGGGCCAAGTAGTTTTACAGCTGCTCCTACTGGGACTACTATTAAAT TTAACCCTCCAACTGGTACAGATACTATGGTCAAAGCTGGAGTTAGCACTAACATAAGTACCAAGCACCA GTGTATTACTGCTATGAAAGAATATGAAAGCAAGTCACTAGAGGAACTTCGTTTAGAGGATTATCAGGCT AACAGGAAGGGCCCACAGAACCAGGTGGGAGCAGGTACCACAACTGGCTTGTTTGGGTCTTCTCCAGCCA CTTCCAGCGCAACAGGACTCTTCAGCTCCTCCACCACTAATTCAGGCTTTGCATATGGTCAGAACAAAAC TGCCTTTGGAACTAGTACAACTGGATTTGGAACAAATCCAGGTGGTCTCTTTGGCCAACAGAATCAGCAG ACTACCAGCCTCTTCAGCAAACCATTTGGCCAGGCTACAACCACCCAGAACACTGGCTTTTCCTTTGGTA ATACCAGCACCATAGGACAGCCAAGCACCAACACCATGGGATTATTTGGAGTAACCCAAGCCTCACAGCC TGGAGGTCTTTTTGGGACAGCTACAAACACCAGCACTGGGACAGCATTTGGAACAGGAACAGGTCTCTTT GGGCAGACCAATACTGGATTTGGTGCTGTTGGTTCGACCCTGTTTGGCAATAACAAGCTTACTACATTTG GAAGCAGCACAACCAGTGCACCTTCATTTGGTACAACCAGTGGCGGGCTCTTTGGTAACAAACCAACCCT GACTTTAGGAACCAATACAAACACTTCTAATTTTGGTTTTGGCACAAATACCAGTGGGAATAGTATTTTT GGAAGTAAACCAGCACCTGGGACTCTTGGAACTGGGCTTGGTGCAGGATTTGGAACAGCTCTTGGTGCTG GACAGGCATCTTTGTTTGGGAACAACCAACCTAAGATTGGAGGGCCTCTTGGTACAGGAGCCTTTGGGGC CCCTGGATTTAATACTACGACAGCCACTTTGGGCTTTGGAGCCCCCCAGGCCCCAGTAGCTTTGACAGAT CCAAATGCTTCTGCTGCCCAGCAGGCTGTTCTCCAGCAGCACATCAATAGTCTAACATACTCACCTTTTG GAGACTCTCCTCTCTTCCGGAATCCGATGTCAGACCCTAAGAAGAAGGAAGAGAGATTGAAACCAACAAA TCCAGCAGCCCAGAAGGCTCTTACTACACCTACTCATTATAAACTGACACCCCGCCCTGCCACTAGAGTC CGGCCAAAGGCTTTACAAACAACAGGCACAGCCAAGTCACATCTCTTTGATGGGCTGGATGACGATGAAC CATCCCTAGCCAATGGAGCATTCATGCCCAAGAAGAGCATTAAGAAGTTGGTTTTGAAGAACCTTAATAA TAGCAATCTCTTTTCTCCTGTTAATCGTGATTCAGAAAATCTAGCTTCACCATCTGAATATCCAGAAAAT GGAGAGAGATTTAGTTTCCTAAGCAAACCTGTTGATGAGAATCACCAGCAGGATGGAGATGAAGATTCCC TTGTTTCACATTTTTATACTAACCCTATTGCCAAACCTATTCCTCAAACCCCAGAAAGTGCTGGAAATAA ACACAGCAACAGCAACAGTGTGGATGATACCATTGTTGCATTAAACATGCGTGCTGCTTTGCGAAATGGG CTGGAAGGAAGCAGTGAAGAAACGTCTTTTCATGATGAGTCACTTCAGGATGACCGAGAAGAAATAGAAA ATAATTCTTACCATATGCACCCAGCAGGTATTATTCTCACTAAGGTTGGTTACTATACTATTCCATCTAT GGATGACCTTGCTAAAATTACCAATGAAAAAGGAGAGTGCATTGTCTCTGATTTCACTATTGGTCGGAAA GGTTATGGTTCAATCTATTTTGAAGGAGATGTGAATTTGACAAATCTAAATTTGGATGATATTGTGCATA TCCGGAGGAAAGAAGTAGTTGTCTACTTAGATGATAACCAAAAACCACCTGTGGGTGAAGGGCTAAATAG GAAGGCTGAAGTTACATTGGATGGAGTTTGGCCAACAGATAAAACATCTCGTTGTTTAATAAAGAGCCCA GATCGCCTTGCTGATATCAACTATGAAGGAAGATTGGAAGCAGTTTCAAGGAAACAGGGAGCTCAATTCA AAGAATACCGGCCTGAAACTGGTTCTTGGGTGTTTAAGGTCTCCCATTTTTCTAAGTATGGCCTTCAGGA TTCTGATGAAGAGGAGGAGGAGCATCCGTCTAAAACTAGTACAAAGAAGTTGAAGACTGCTCCTTTGCCT CCTGCAAGCCAGACTACGCCCTTGCAGATGGCTCTTAATGGCAAACCTGCACCTCCACCTCAGGTAGAGA AAAAAGGACAGTGA >OriGene 5' read for NM_005387 unedited
GGGTGCACGATATTTGTNAATCCGNATTTCACTATAGGNCGGCACGCGCAATTCGGCACG AGGCGCGCTGCGCCCGAACGGCGGTCGGTGGCAGGGGTGGTAGCGGCGGCGGCGACGGTT TCGTGGGGGCCGCGCGCTGCTCTGTGAGCGGCGGGTGGCAGCAGGGGACTCCTGACACTT CCCCTTCCCCACCGAACCGCGCTTTCTGAAACAAATTCTTANNTTGAAGATGTTTAACAA ATCATTTGGAACACCCTTTGGGGGTGGCACAGGTGGCTTTGGCACAACTTCAACATTTGG ACAGAATACTGGCTTTGGCACTACTAGTGGAGGGGCATTTGGAACATCTGCATTTGGTTC TAGCAACAATACTGGAGGCCTCTTTGGAAATTCACAGACTAAACCAGGAGGATTGTTTGG AACCAGTTCATTTAGCCAGCCAGCTACCTCCACAAGCACTGGCTTTGGGTTTGGTACGTC AACAGGAACAGCAAATACCTTGTTTGGAACTGCAAGCACAGGGACCAGTCTCTTCTCATC CCAAAACAATGCTTTTGCACAAAATAAACCAACTGGCTTTGGCAATTTTGGAACCAGTAC TAGCAGTGGAGGACTCTTTGGGACCACAAATACCACCTCTAATCCTTTTGGCAGCACATC TGGCTCCCTCTTTGGGCCAAGTAGTTTTACAGCTGCTCCTACTGGGACTACTATTAAATT AAACCCTCCCACTGGTACAGATACTATGGTCAAAGCTGGAGTTAGCCCTAACATTAGTTC CAAGCACCAATGTTTTACTGCTCTGGAAGAAAATGAAAAGCAGTCACTAGAAGAACTTCG TTTAAAGGATATTAGGCTTACAGGAAGGCCCCCCAAAACCGGTGGGGACAGGTCCCAAAC CGGGTTGGTTGGGTCTTCTCCACCACTTCCAAGC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005387 |
| Insert Size | 4000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_005387.4, NP_005378.4 |
| RefSeq Size | 3829 bp |
| RefSeq ORF | 2814 bp |
| Locus ID | 4928 |
| UniProt ID | P52948 |
| Domains | Nucleoporin_FG, Nucleoporin2 |
| Protein Families | Druggable Genome |
| Gene Summary | Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016] Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, lacks multiple exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has an additional internal segment and a shorter and distinct C-terminus, compared to isoform 1. This isoform (3) may undergo proteolytic processing similar to that of isoform 2. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC214609 | NUP98 (Myc-DDK-tagged)-Human nucleoporin 98kDa (NUP98), transcript variant 3 |
CNY 7,552.00 |
|
| RC214609L3 | Lenti-ORF clone of NUP98 (Myc-DDK-tagged)-Human nucleoporin 98kDa (NUP98), transcript variant 3 |
CNY 11,690.00 |
|
| RC214609L4 | Lenti-ORF clone of NUP98 (mGFP-tagged)-Human nucleoporin 98kDa (NUP98), transcript variant 3 |
CNY 11,690.00 |
|
| RG214609 | NUP98 (tGFP-tagged) - Human nucleoporin 98kDa (NUP98), transcript variant 3 |
CNY 10,740.00 |
