SP110 (NM_004509) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	IFI41; IFI75; IPR1; VODI
Vector	pCMV6-XL4
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for NM_004509 edited AGTGATCCCTGTCCCAGCCCCTGGAAAGGGGCAGGAACGACAAACTCAAAGTCCAGGATG TTCACCATGACAAGAGCCATGGAAGAGGCTCTTTTTCAGCACTTCATGCACCAGAAGCTG GGGATCGCCTATGCCATACACAAGCCATTTCCCTTCTTTGAAGGCCTCCTAGACAACTCC ATCATCACTAAGAGAATGTACATGGAATCTCTGGAAGCCTGTAGAAATTTGATCCCTGTA TCCAGAGTGGTGCACAACATTCTCACCCAACTGGAGAGGACTTTTAACCTGTCTCTTCTG GTGACATTGTTCAGTCAAATTAACCTGCGTGAATATCCCAATCTGGTGACGATTTACAGA AGCTTCAAACGTGTTGGTGCTTCCTATGAACGGCAGAGCAGAGACACACCAATCCTACTT GAAGCCCCAACTGGCCTAGCAGAAGGAAGCTCCCTCCATACCCCACTGGCGCTGCCCCCA CCACAACCCCCTCAACCAAGCTGTTCACCCTGTGCGCCAAGAGTCAGTGAGCCTGGAACA TCCTCCCAGCAAAGCGATGAGATCCTGAGTGAGTCGCCCAGCCCATCTGACCCTGTCCTG CCTCTCCCTGCACTCATCCAGGAAGGAAGAAGCACTTCAGTGACCAATGACAAGTTAACA TCCAAAATGAATGTGGAAGAAGACTCAGAAGAGATGCCCAGCCTCCTCACTAGCACTGTG CAAGTGGCCAGTGACAACCTGATCCCCCAAATAAGAGATAAAGAAGACCCTCAAGAGATG CCCCACTCTCCCTTGGGCTCTATGCCAGAGATAAGAGATAATTCTCCAGAACCAAATGAC CCAGAAGAGCCCCAGGAGGTGTCCAGCACACCTTCAGACAAGAAAGGAAAGAAAAGAAAA AGATGTATCTGGTCAACTCCAAAAAGGAGACATAAGAAAAAAAGCCTCCCAAGAGGGACA GCCTCATCTAGACACGGAATCCAAAAGAAGCTCAAAAGGGTGGATCAGGTTCCTCAAAAG AAAGATGACTCAACTTGTAACTCCACGGTAGAGACAAGGGCCCAAAAGGCGAGAACTGAA TGTGCCCGAAAGTCGAGATCAGAGGAGATCATTGATGGCACTTCAGAAATGAATGAAGGA AAGAGGTCCCAGAAGACGCCTAGTACACCACGAAGGGTCACACAAGGGGCAGCCTCACCT GGGCATGGCATCCAAGAGAAGCTCCAAGTGGTGGATAAGGTGACTCAAAGGAAAGACGAC TCAACCTGGAACTCAGAGGTCATGATGAGGGTCCAAAAGGCAAGAACTAAATGTGCCCGA AAGTCCAGATCGAAAGAAAAGAAAAAGGAGAAAGATATCTGTTCAAGCTCAAAAAGGAGA TTTCAGAAAAATATTCACCGAAGAGGAAAACCCAAAAGTGACACTGTGGATTTTCACTGT TCTAAGCTCCCCGTGACCTGTGGTGAGGCGAAAGGGATTTTATATAAGAAGAAAATGAAA CACGGATCCTCAGTGAAGTGCATTCGGAATGAGGATGGAACTTGGTTAACACCAAATGAA TTTGAAGTCGAAGGAAAAGGAAGGAACGCAAAGAACTGGAAACGGAATATACGTTGTGAA GGAATGACCCTAGGAGAGCTGCTGAAGCGGAAAAACTCGGATGAATGCGAGGTGTGCTGT CAAGGGGGACAACTTCTCTGCTGCGGTACTTGTCCACGAGTCTTCCATGAGGACTGTCAC ATCCCCCCTGTGGAAGCCAAGAGGATGCTGTGGAGTTGCACCTTCTGCAGGATGAAGAGG TCTTCAGGAAGCCAACAGTGCCATCATGTATCTAAGACCCTGGAGAGGCAGATGCAGCCT CAGGACCAGCTGATTCGAGATTACGGTGAGCCCTTTCAGGAAGCAATGTGGTTGGACCTG GTTAAGGAAAGGCTGATTACGGAAATGTACACGGTGGCATGGTTTGTGCGAGACATGCGC CTGATGTTTCGCAACCATAAAACATTTTACAAGGCTTCTGACTTTGGCCAGGTAGGACTT GACTTAGAGGCAGAATTTGAAAAAGATCTCAAAGACGTGCTCGGTTTTCATGAAGCCAAT GACGGCGGTTTCTGGACTCTTCCTTGACCCTGTTCTGTAAAGACTGAAGCATCCCCACCT CAGGATTCAGCTGATGGGACCCTGGCTTGGACTGTTGATTGCCAGTGAGTCTGGGATGTA ATTGGCTGCCCTCAGGACCCAAACCCAGACACTTCATAGGATTATCACACCCTCCATCTT TATTCTTTCTTTTTACCTTTAAAAGTCTATATCTACACTAAAAAAAAAAAAAAAAAAA
Restriction Sites	Please inquire
ACCN	NM_004509
Insert Size	2300 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	It is not a varient.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_004509.2, NP_004500.2
RefSeq Size	2359 bp
RefSeq ORF	2070 bp
Locus ID	3431
UniProt ID	Q9HB58
Domains	SAND, BROMO, PHD, Sp100
Protein Families	Druggable Genome, Transcription Factors
Gene Summary	The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (a) lacks an internal alternate exon in the 3' coding region, compared to variant c. The resulting protein (isoform a) has a truncated bromodomain region when it is compared to isoform c.

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