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Rnf128 (NM_023270) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206827L4V
- LentiORF®
-
Lenti ORF particles, Rnf128 (GFP-tagged) - Mouse ring finger protein 128 (Rnf128), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Rnf128 (NM_023270) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1300002C13Rik; AI987883; GRAIL; Greul1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_023270 |
| ORF Size | 1284 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206827).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_023270.5, NP_075759.3 |
| RefSeq Size | 2764 bp |
| RefSeq ORF | 1287 bp |
| Locus ID | 66889 |
| Gene Summary | E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity).[UniProtKB/Swiss-Prot Function] |
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