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Khdrbs1 (NM_011317) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR207062L3V
- LentiORF®
-
Lenti ORF particles, Khdrbs1 (Myc-DDK-tagged) - Mouse KH domain containing, RNA binding, signal transduction associated 1 (Khdrbs1), 200ul, >10^7 TU/mL
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CNY 8,835.00
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Specifications
| Product Data | |
| Product Name | Khdrbs1 (NM_011317) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | p62; p68; Sam68 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_011317 |
| ORF Size | 1329 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR207062).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011317.4, NP_035447.3 |
| RefSeq Size | 3762 bp |
| RefSeq ORF | 1332 bp |
| Locus ID | 20218 |
| Gene Summary | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (By similarity). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (PubMed:12478298, PubMed:22196734, PubMed:24469635).[UniProtKB/Swiss-Prot Function] |
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