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Nphp4 (NM_153424) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR216552L4V
- LentiORF®
-
Lenti ORF particles, Nphp4 (GFP-tagged) - Mouse nephronophthisis 4 (juvenile) homolog (human) (Nphp4), 200ul, >10^7 TU/mL
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CNY 22,230.00
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Specifications
| Product Data | |
| Product Name | Nphp4 (NM_153424) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 4930564O18Rik; nmf192 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_153424 |
| ORF Size | 4278 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR216552).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_153424.2, NP_700473.2 |
| RefSeq Size | 5047 bp |
| RefSeq ORF | 4278 bp |
| Locus ID | 260305 |
| Gene Summary | Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (By similarity). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (By similarity).[UniProtKB/Swiss-Prot Function] |
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