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Usp30 (NM_001033202) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226441L3V
- LentiORF®
-
Lenti ORF particles, Usp30 (Myc-DDK-tagged) - Mouse ubiquitin specific peptidase 30 (Usp30), 200ul, >10^7 TU/mL
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CNY 9,690.00
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规格
| Cited in 1 publication. |
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经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Usp30 (NM_001033202) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 6330590F17Rik; AI851327; D5Ertd483e |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001033202 |
| ORF Size | 1551 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226441).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001033202.3, NP_001028374.1 |
| RefSeq Size | 2790 bp |
| RefSeq ORF | 1554 bp |
| Locus ID | 100756 |
| Gene Summary | Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (By similarity). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (PubMed:24513856).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Parkin interacts with Mitofilin to increase dopaminergic neuron death in response to Parkinson’s disease-related stressors
,null,
American Journal of Translational Research
,PubMed ID 33312388
[Usp30]
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