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DOCK2 (NM_004946) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC211198L1V
- LentiORF®
-
Lenti ORF particles, DOCK2 (Myc-DDK tagged) - Human dedicator of cytokinesis 2 (DOCK2), 200ul, >10^7 TU/mL
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CNY 21,660.00
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Specifications
| Product Data | |
| Product Name | DOCK2 (NM_004946) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | IMD40 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_004946 |
| ORF Size | 5490 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC211198).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_004946.1 |
| RefSeq Size | 6050 bp |
| RefSeq ORF | 5493 bp |
| Locus ID | 1794 |
| Protein Families | Druggable Genome |
| Protein Pathways | Chemokine signaling pathway, Fc gamma R-mediated phagocytosis |
| MW | 211.8 kDa |
| Gene Summary | The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018] |
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