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IDN3 (NIPBL) (NM_133433) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC211489L1V
- LentiORF®
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Lenti ORF particles, NIPBL (Myc-DDK tagged) - Human Nipped-B homolog (Drosophila) (NIPBL), transcript variant A, 200ul, >10^7 TU/mL
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CNY 21,660.00
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规格
| Cited in 1 publication. |
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经常一起买 (3)
Specifications
| Product Data | |
| Product Name | IDN3 (NIPBL) (NM_133433) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CDLS; CDLS1; IDN3; IDN3-B; Scc2 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_133433 |
| ORF Size | 8412 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC211489).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_133433.2 |
| RefSeq Size | 9717 bp |
| RefSeq ORF | 8415 bp |
| Locus ID | 25836 |
| MW | 315.9 kDa |
| Gene Summary | This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome
,null,
Nature Communications
,PubMed ID 34315879
[NIPBL]
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