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PHF19 (NM_001009936) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC220691L3V
- LentiORF®
-
Lenti ORF particles, PHF19 (Myc-DDK-tagged)-Human PHD finger protein 19 (PHF19), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | PHF19 (NM_001009936) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | MTF2L1; PCL3; TDRD19B |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001009936 |
| ORF Size | 621 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC220691).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001009936.1 |
| RefSeq Size | 1001 bp |
| RefSeq ORF | 624 bp |
| Locus ID | 26147 |
| Protein Families | Druggable Genome |
| MW | 22.3 kDa |
| Gene Summary | Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.[UniProtKB/Swiss-Prot Function] |
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