Human Mineralocorticoid Receptor (NR3C2) activation kit by CRISPRa
CAT#: GA102930
NR3C2 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 3 group C member 2
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | NR3C2 |
Locus ID | 4306 |
Kit Components | GA102930G1, Mineralocorticoid Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102930G2, Mineralocorticoid Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102930G3, Mineralocorticoid Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_000901, NM_001166104, NM_001354819, NR_148974 |
Synonyms | MCR; MLR; MR; NR3C2VIT |
Summary | This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN420558 | NR3C2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |