Human ZNF568 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZNF568
Locus ID	374900
Kit Components	GA117790G1, ZNF568 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117790G2, ZNF568 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117790G3, ZNF568 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001204835, NM_001204836, NM_001204837, NM_001204838, NM_001204839, NM_198539
Synonyms	DKFZp667O0524; DKFZp686B0797; FLJ34820; FLJ35804
Summary	Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.[UniProtKB/Swiss-Prot Function]

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