Mouse Ripk3 activation kit by CRISPRa

CAT#: GA206024

Ripk3 CRISPRa kit - CRISPR gene activation of mouse receptor-interacting serine-threonine kinase 3



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (2)
Rabbit Polyclonal RIP3 Antibody
    • 100 ug

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Phospho-RIP3-T231/S232 Rabbit polyclonal Antibody
    • 100 ul

CNY 2,900.00

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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Ripk3
Locus ID 56532
Kit Components

GA206024G1, Ripk3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA206024G2, Ripk3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA206024G3, Ripk3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001164107, NM_001164108, NM_019955
Synonyms 2610528K09Rik; AW107945; Rip3
Summary Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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