Neurofibromin (NF1) Human Gene Knockout Kit (CRISPR)

CAT#: KN220378

NF1 - human gene knockout kit via CRISPR, HDR mediated




 HDR-mediated knockout kit validation

  See Other Versions

CNY 12,260.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
    • 10 ug

CNY 3,710.00


NF1 rabbit polyclonal antibody
    • 25 ul

CNY 800.00
CNY 1,280.00


Lenti ORF particles, NF1 (Myc-DDK tagged) - Human neurofibromin 1 (NF1), transcript variant 3, 200ul, >10^7 TU/mL
    • 200 ul

CNY 10,545.00

Specifications

Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Donor DNA GFP-puro
Symbol Neurofibromin
Locus ID 4763
Kit Components

KN220378G1, Neurofibromin gRNA vector 1 in pCas-Guide CRISPR vector

KN220378G2, Neurofibromin gRNA vector 2 in pCas-Guide CRISPR vector

KN220378-D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000267, NM_001042492, NM_001128147
Synonyms NFNS; VRNF; WSS
Summary This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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