Vhl Mouse Gene Knockout Kit (CRISPR)
CAT#: KN318888RB
Vhl - mouse gene knockout kit via CRISPR, HDR mediated
HDR-mediated knockout kit validation
CNY 12,260.00
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | Vhl |
Locus ID | 22346 |
Kit Components |
KN318888G1, Vhl gRNA vector 1 in pCas-Guide CRISPR vector KN318888G2, Vhl gRNA vector 2 in pCas-Guide CRISPR vector KN318888RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_009507 |
Synonyms | Vhlh |
Summary | Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN318888 | Vhl - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN318888BN | Vhl - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN318888LP | Vhl - mouse gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN518888 | Vhl - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
|
GA204595 | Vhl CRISPRa kit - CRISPR gene activation of mouse von Hippel-Lindau tumor suppressor |
CNY 12,255.00 |