Apoptosis enhancing nuclease (AEN) (NM_022767) Human Mass Spec Standard

Specifications

Product Data
Description	AEN MS Standard C13 and N15-labeled recombinant protein (NP_073604)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC202285
Predicted MW	36.4 kDa
Protein Sequence	Sequence Link (showhide) >RC202285 protein sequence Red=Cloning site Green=Tags(s) MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGA ATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGD VLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQ TRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARS LWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_073604
RefSeq Size	3134
RefSeq ORF	975
Synonyms	ISG20L1; pp12744
Locus ID	64782
Cytogenetics	15q26.1
Summary	Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.[UniProtKB/Swiss-Prot Function]

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