CD247 (NM_000734) Human Mass Spec Standard

Specifications

Product Data
Description	CD247 MS Standard C13 and N15-labeled recombinant protein (NP_000725)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC206562
Predicted MW	18.7 kDa
Protein Sequence	Sequence Link (showhide) >RC206562 protein sequence Red=Cloning site Green=Tags(s) MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSADAPAYQQGQNQ LYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKGERRRGKGHDG LYQGLSTATKDTYDALHMQALPPR TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_000725
RefSeq Size	1687
RefSeq ORF	492
Synonyms	CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ
Locus ID	919
Cytogenetics	1q24.2
Summary	The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

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