MTRFR (NM_152269) Human Mass Spec Standard

Specifications

Product Data
Description	C12orf65 MS Standard C13 and N15-labeled recombinant protein (NP_689482)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC209162
Predicted MW	18.8 kDa
Protein Sequence	Sequence Link (showhide) >RC209162 protein sequence Red=Cloning site Green=Tags(s) MSTVGLFHFPTPLTRICPAPWGLRLWEKLTLLSPGIAVTPVQMAGKKDYPALLSLDENELEEQFVKGHGP GGQATNKTSNCVVLKHIPSGIVVKCHQTRSVDQNRKLARKILQEKVDVFYNGENSPVHKEKREAAKKKQE RKKRAKETLEKKKLLKELWESSKKVH TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_689482
RefSeq Size	1692
RefSeq ORF	498
Synonyms	C12orf65; COXPD7; SPG55
Locus ID	91574
Cytogenetics	12q24.31
Summary	This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

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