PML Protein (PML) (NM_033239) Human Mass Spec Standard

CAT#: PH312067

PML MS Standard C13 and N15-labeled recombinant protein (NP_150242)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description PML MS Standard C13 and N15-labeled recombinant protein (NP_150242)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC212067
Predicted MW 90.5 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_150242
RefSeq Size 3088
RefSeq ORF 2487
Synonyms MYL; PP8675; RNF71; TRIM19
Locus ID 5371
Cytogenetics 15q24.1
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis
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