Bcl2 Binding component 3 (BBC3) (NM_014417) Human Mass Spec Standard

Specifications

Product Data
Description	BBC3 MS Standard C13 and N15-labeled recombinant protein (NP_055232)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC213203
Predicted MW	20.4 kDa
Protein Sequence	Sequence Link (showhide) >RC213203 representing NM_014417 Red=Cloning site Green=Tags(s) MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLCAPTAPPAVTA ALGGSRWPGGPRSRPRGPRPDGPQPSLSLAEQHLESPVPSAPGALAGGPTQAAPGVRGEEEQWAREIGAQ LRRMADDLNAQYERRRQEEQQRHRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_055232
RefSeq Size	1840
RefSeq ORF	579
Synonyms	JFY-1; JFY1; PUMA
Locus ID	27113
Cytogenetics	19q13.32
Summary	This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease, p53 signaling pathway

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