Heat shock protein 70 / HSP70 (active) Human Protein
CAT#: AR03018PU-L
Heat shock protein 70 / HSP70 (active) human recombinant protein, 2x0.1 mg
Size: 50 ug
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CNY 11,410.00
货期*
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规格
Cited in 9 publications. |
Product images
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Concentration | lot specific |
Purity | >90% pure as determined by SDS-PAGE analysis. |
Buffer | Presentation State: Purified State: Liquid affinity purified protein. Buffer System: Sodium Phosphate, pH 7.5 (20 mM), 150 mM NaCl, 10% Glycerol, 200 mM Imidazole. |
Preparation | Liquid affinity purified protein. |
Applications | ATPase Assay. Western B Control. Binding Assays. ELISA reference standard. Lipid Interaction Assays. |
Protein Description | Recombinant Human Hsp70 Protein with ATPase activity, his-tagged, cloned from a Human cDNA library |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Bioactivity | Biological: The protein has ATPase activity at the time of manufacture of 3.3 μM phosphate liberated/hr/μg protein in a 200 μl reaction at 37°C (pH7.5) in the presence of 20 µl of 1mM ATP using a Malachite Green assay. |
Reference Data | |
RefSeq | NP_005336 |
Locus ID | 3303 |
UniProt ID | P08107, P0DMV8, P0DMV9, A8K5I0, B3KTT5 |
Cytogenetics | 6p21.33 |
Synonyms | HEL-S-103; HSP70-1; HSP70-1A; HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1 |
Summary | This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008] |
Protein Pathways | Antigen processing and presentation, Endocytosis, MAPK signaling pathway, Prion diseases, Spliceosome |
Citations (9)
The use of this Proteins has been cited in the following citations: |
---|
Impacts of Deoxygenation and Hypoxia on Shark Embryos Anti-Predator Behavior and Oxidative Stress
,null,
Biology
,PubMed ID 37106777
[HSPA1A]
|
Does Predation Exacerbate the Risk of Endosymbiont Loss in Heat Stressed Hermatypic Corals? Molecular Cues Provide Insights Into Species-Specific Health Outcomes in a Multi-Stressor Ocean
,null,
Frontiers in Physiology
,PubMed ID 35299660
[HSPA1A]
|
Warming enhances lanthanum accumulation and toxicity promoting cellular damage in glass eels (Anguilla anguilla).
,null,
Environmental research
,PubMed ID 32818498
[HSPA1A]
|
Toxicity Evaluation of Quantum Dots (ZnS and CdS) Singly and Combined in Zebrafish (Danio rerio)
,null,
International Journal of Environmental Research and Public Health
,PubMed ID 31905638
[HSPA1A]
|
Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
,null,
Nature Communications
,PubMed ID 30446660
[HSPA1A]
|
Irradiation Enhances Abscopal Anti-tumor Effects of Antigen-Specific Immunotherapy through Regulating Tumor Microenvironment
,null,
Molecular Therapy
,PubMed ID 29248428
[HSPA1A]
|
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
,null,
Nature Communications
,PubMed ID 29242535
[HSPA1A]
|
Proteomic analysis reveals heat shock protein 70 has a key role in polycythemia Vera
,null,
Molecular Cancer
,PubMed ID 24252366
[HSPA1A]
|
The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes
,null,
PLoS Pathogens
,PubMed ID 24204260
[HSPA1A]
|
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