CD253 / TRAIL (114-281) Human Protein
CAT#: AR09088PU-L
CD253 / TRAIL (114-281) human recombinant protein, 0.5 mg
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CNY 12,210.00
货期*
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规格
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNG ELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWS KDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG
|
Concentration | lot specific |
Purity | ≥95 by SDS-PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris pH 7.5, 300 mM NaCl, 0.1 mM DTT, 10% glycerol |
Preparation | Liquid purified protein |
Protein Description | Recombinant human TRAIL was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001177871 |
Locus ID | 8743 |
UniProt ID | P50591 |
Cytogenetics | 3q26.31 |
Synonyms | Apo-2L; APO2L; CD253; TL2; TNLG6A; TRAIL |
Summary | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity |
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