WDR5 / BIG3 (1-334, His-tag) Human Protein
CAT#: AR09569PU-L
WDR5 / BIG3 (1-334, His-tag) human recombinant protein, 0.5 mg
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CNY 14,920.00
货期*
详询
规格
Cited in 5 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH TDVVISTACH PTENIIASAA LENDKTIKLW KSDC
|
Tag | His-tag |
Predicted MW | 38.8 kDa |
Concentration | lot specific |
Purity | >95% by SDS – PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2 mM DTT, 0.1 M NaCl |
Preparation | Liquid purified protein |
Protein Description | Recombinant human WDR5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_060058 |
Locus ID | 11091 |
UniProt ID | P61964 |
Cytogenetics | 9q34.2 |
Synonyms | BIG-3; CFAP89; SWD3 |
Summary | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Citations (5)
The use of this Proteins has been cited in the following citations: |
---|
TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis
,null,
Cancer research
,PubMed ID 28484075
[WDR5]
|
High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila
,null,
eLife
,PubMed ID 28084990
[WDR5]
|
WDR5 high expression and its effect on tumorigenesis in leukemia
,null,
Oncotarget
,PubMed ID 27192115
[WDR5]
|
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.
,null,
Cancer research
,PubMed ID 26471359
[WDR5]
|
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
,null,
Cell
,PubMed ID 21477851
[WDR5]
|
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