RAB7A / RAB7 (1-207, His-tag) Human Protein
CAT#: AR09817PU-L
RAB7A / RAB7 (1-207, His-tag) human recombinant protein, 0.5 mg
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CNY 14,920.00
货期*
详询
规格
Cited in 3 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV MVDDRLVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVFDV TAPNTFKTLD SWRDEFLIQA SPRDPENFPF VVLGNKIDLE NRQVATKRAQ AWCYSKNNIP YFETSAKEAI NVEQAFQTIA RNALKQETEV ELYNEFPEPI KLDKNDRAKA SAESCSC
|
Tag | His-tag |
Predicted MW | 25.6 kDa |
Concentration | lot specific |
Purity | >90% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 30% glycerol, 100 mM NaCl |
Preparation | Liquid purified protein |
Protein Description | Recombinant human RAB7A protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_004628 |
Locus ID | 7879 |
UniProt ID | P51149, A0A158RFU6 |
Cytogenetics | 3q21.3 |
Synonyms | CMT2B; PRO2706; RAB7 |
Summary | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
Citations (3)
The use of this Proteins has been cited in the following citations: |
---|
Presumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiency
,null,
Scientific Reports
,PubMed ID 27682851
[RAB7A]
|
Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy.
,null,
Journal of physiology and biochemistry
,PubMed ID 25773064
[RAB7A]
|
Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin
,null,
Acta Neuropathologica
,PubMed ID 23179371
[RAB7A]
|
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