PDCD10 (His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGSSHHHHHHSSGLVPRGSM RMTMEEMKNE AETTSMVSMP LYAVMYPVFN ELERVNLSAA QTLRAAFIKA EKENPGLTQD IIMKILEKKS VEVNFTESLL RMAADDVEEY MIERPEPEFQ DLNEKARLKQ ILSKIPDEIN DRVRFLQTIK DIASAIKELL DTVNNVFKKY QYQNRRALEH QKKEFVKYSK SFSDTLKTYF KDGKAINVFV SANRLIHQTN LILQTFKTVA
Tag	His-tag
Predicted MW	26.7 kDa
Purity	>95% by SDS-PAGE and silver stain
Buffer	Presentation State: Purified State: Lyophilized protein Buffer System: PBS Stabilizer: None
Preparation	Lyophilized protein
Protein Description	Human recombinant PDCD10 fragment, aa. 231
Note	Protein RefSeq: NP_009148.2 mRNA RefSeq: NM_007217.3
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Endotoxin	< 0.1 ng/µg of CCM-3
Reference Data
RefSeq	NP_009148
Locus ID	11235
UniProt ID	Q9BUL8
Cytogenetics	3q26.1
Synonyms	CCM3, TFAR15
Summary	This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome

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