Gremlin-1 / GREM1 Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Predicted MW	19.7 kDa
Purity	>95% pure by SDS-PAGE and visualised by silver stain
Buffer	Presentation State: Purified State: Lyophilized purified fraction Buffer System: PBS Stabilizer: None
Preparation	Lyophilized purified fraction
Protein Description	Recombinant Human FGR-4. Result by N-terminal sequencing: MAPTAPNGTL
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Bioactivity	Biological: The biological activity was determined by the induction of proliferation in NHDF cells (Normal Human Dermal Fibroblasts).
Reference Data
RefSeq	NP_001178251
Locus ID	26585
UniProt ID	B3KTR9
Cytogenetics	15q13.3
Synonyms	DAND2, CKTSF1B1, DRM, PIG2, IHG-2, GREM-1
Summary	This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Protein Families	ES Cell Differentiation/IPS, Secreted Protein

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