Klotho Human Protein

Specifications

Product Data
Species	Human
Expression Host	CHO
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGG WQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD V ASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGL RYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DH FRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSP RL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPR RMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDF T ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQL LSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKML LPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH
Predicted MW	65-70 kDa
Purity	>98% by SDS-PAGE and HPLC
Buffer	Presentation State: Purified State: Lyophilized purified protein Stabilizer: None
Preparation	Lyophilized purified protein
Protein Description	Recombinant Human Klotho is a 65-70 kDa glycoprotein containing 516 amino acid residues.
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Bioactivity	Biological: Determined by the dose-dependent stimulation of the proliferation of murine NIH-3T3 cells. Recombinant human Klotho is effective in a concentration range of 0.5-2.0 μg/ml.
Reference Data
RefSeq	NP_004786
Locus ID	9365
UniProt ID	Q9UEF7
Cytogenetics	13q13.1
Synonyms	KL, Klotho, EC 3.2.1.31
Summary	This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
Protein Families	Secreted Protein, Transmembrane

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