KITLG / SCF Human Protein

Specifications

Product Data
Species	Human
Expression Host	Insect
Predicted MW	18.4 kDa
Purity	>95% 95% by SDS-PAGE and visualised by silver stain
Buffer	Presentation State: Purified State: Lyophilized purified protein Buffer System: PBS, pH 7.4, without stabilizer
Preparation	Lyophilized purified protein
Protein Description	Recombinant Human Stem Cell Factor (SCF) His-tag. Soluble Stem Cell Factor (SCF), a 18.4kDa protein consisting of 165 amino acid residues (Glu26-Ala190) and fused to a C-terminal His-tag (6x His).
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Bioactivity	Biological: Measured in a cell proliferation assay using TF 1 human erythroleukemic cells [Kitamura T et al, J Cell Physiol, 1989]. The ED50 for this effect is typically 1‑5 ng/ml.
Endotoxin	< 0.1 ng per µg of SCF
Reference Data
RefSeq	NP_000890
Locus ID	4254
UniProt ID	P21583
Cytogenetics	12q21.32
Synonyms	KITL, Kit ligand, c-Kit ligand, Stem cell factor, Mast cell growth factor, MGF
Summary	This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer

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