Agouti-related protein / AGRP Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MKHHHHHHHM LVPRGSAQMG LAPMEGIRRP DQALLPELPG LGLRAPLKKT TAEQAEEDLL QEAQALAEVL DLQDREPRSS RRCVRLHESC LGQQVPCCDP CATCYCRFFN AFCYCRKLGT AMNPCSRT
Concentration	lot specific
Purity	>95%
Buffer	Presentation State: Purified State: Lyophilized purified protein Buffer System: 5 mM TRIS, 25 mM NaCl, pH 7.5
Preparation	Lyophilized purified protein
Applications	ELISA. Western Blot.
Protein Description	Total 128 AA. MW: 14.4 kDa (calculated). N-Terminal His-tag, 16 extra AA (highlighted).
Storage	Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after two weeks at 4°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001129
Locus ID	181
UniProt ID	O00253
Cytogenetics	16q22.1
Synonyms	AGRT, ART
Summary	This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Protein Families	ELISA. Western Blot.
Protein Pathways	Adipocytokine signaling pathway

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