Exd1 (NM_172857) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR219928 representing NM_172857 Red=Cloning site Green=Tags(s) MDPSSDYHFLNQILWRRVKLTLVSGIFEGVLQHVDPNKIVVLKNVRNAESGRSVPGVKVFFGHEILNVEL MDEAEGASGEKASAVSINTERAGMEKVKNEDVNVCEPASPAPEVPTSSLLSDLKYCPSEEEEVTYTVIDQ FQQKFGAAMLHIKKQSVLSVAAEGANVCRHGKLCWLQVATNSRVYLFDIFLLGSRAFNNGLQMILEDKRI LKVIHDCRWLSDCLSHQYGIMLNNVFDTQVADVLQFSMETGGFLPNCISTLQESLIRHLKVAPRYLFFLE ERQKRIQENPEIWLTRPLPPSLLKILALETTYLLPLRLVLLDEVMSDLTTLVDGYLNTYREGSADRLAGT EPACMELPAELLQLQDFQKQRRERAVKEYRVNARGLLIRTPLHPKEPTACTAGKEERVQGFLFYKTDGGD QVPRFLCPKSHEDEKFLDKESKQTTAKSQIVPPRKEGEAHKDSKNKPGCWESAGPEDPRAQKAHALPPTW ASQSQFSLKEEIEQLTVVGNKGALTSPKEGALVSPSLLQETWEAPTDTFHLPEKAEVSTLPPCPALEKTD SWISPSLNLF TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	64 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_766445
Locus ID	241624
UniProt ID	Q8CDF7
Refseq Size	3143
Cytogenetics	2 E5
Refseq ORF	1710
Synonyms	4932702D22Rik; Exdl1; mExd1
Summary	RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (PubMed:26669262). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).[UniProtKB/Swiss-Prot Function]

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