United States
Germany
Japan
United Kingdom
China
Cytochrome P450 2D6 (CYP2D6) (NM_000106) Human Recombinant Protein
CAT＃: TP700027
Recombinant protein of human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1, with C-terminal DDK tag, expressed in human cells
View other "Cytochrome P450 2D6" proteins (8)
|
Need it in bulk or customized? Get a free quote |
Avi-tag Biotinylated Protein Get a free quote |
CNY 6,650.00
Product images
Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
A DNA sequence from TrueORF clone, RC223749, encoding human full-length CYP2D6
|
| Tag | C-DDK |
| Predicted MW | 57 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_000097 |
| Locus ID | 1565 |
| UniProt ID | P10635 |
| Refseq Size | 1673 |
| Cytogenetics | 22q13.2 |
| Refseq ORF | 1491 |
| Synonyms | CPD6; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; P450-DB1; P450C2D; P450DB1 |
| Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Drug metabolism - cytochrome P450 |
Documents
| FAQs |
| SDS |
Resources
| 蛋白相关资源 |
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC422597 | CYP2D6 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC424921 | CYP2D6 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC424985 | CYP2D6 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY422597 | Transient overexpression lysate of cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 2 |
CNY 4,840.00 |
|
| LY424921 | Transient overexpression lysate of cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1 |
CNY 4,840.00 |
|
| LY424985 | Transient overexpression lysate of cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 1 |
CNY 3,080.00 |
|
| PH321660 | CYP2D6 MS Standard C13 and N15-labeled recombinant protein (NP_001020332) |
CNY 19,520.00 |
|
| TP321660 | Recombinant protein of human cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), transcript variant 2, 20 µg |
CNY 2,900.00 |
其它Cytochrome P450 2D6产品
