HTRA1 (NM_002775) Mutant (S328A) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A DNA sequence from TrueORF clone, RC222362 with a T982G mutation, encoding the mutant form (S328A) of human HTRA
Tag	C-Myc/DDK
Predicted MW	49 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity	Protein degradation enzyme (PMID: 29269042) Enzyme activity (PMID: 29572155)
Reference Data
RefSeq	NP_002766
Locus ID	5654
UniProt ID	Q92743
Refseq Size	2133
Cytogenetics	10q26.13
Refseq ORF	1440
Synonyms	ARMD7; CADASIL2; CARASIL; HtrA; L56; ORF480; PRSS11
Summary	This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Protease, Secreted Protein

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